4-[5-amino-1-(4-fluorophenyl)-1H-imidazol-4-yl]-5-imino-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile

Base Information

• Chemical Name: 4-[5-amino-1-(4-fluorophenyl)-1H-imidazol-4-yl]-5-imino-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile
• CAS No.: 1380583-84-5
• Molecular Formula: C₁₄H₉FN₆O
• Molecular Weight: 296.263
• Mol file: 1380583-84-5.mol

Synonyms:4-[5-amino-1-(4-fluorophenyl)-1H-imidazol-4-yl]-5-imino-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile

Chemical Property of 4-[5-amino-1-(4-fluorophenyl)-1H-imidazol-4-yl]-5-imino-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-[5-amino-1-(4-fluorophenyl)-1H-imidazol-4-yl]-5-imino-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile

There total 1 articles about 4-[5-amino-1-(4-fluorophenyl)-1H-imidazol-4-yl]-5-imino-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-amino-1-(4-fluorophenyl)-1H-imidazole-4-carbimidoyl cyanide (155579-36-5) + cyanoacetic acid amide (107-91-5) → 4-[5-amino-1-(4-fluorophenyl)-1H-imidazol-4-yl]-5-imino-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile (1380583-84-5)

Guidance literature:

In ethanol; acetonitrile; at 20 ℃; for 120h;

DOI:10.1016/j.tet.2012.04.030

Reference yield: 89.0%

4-[5-amino-1-(4-fluorophenyl)-1H-imidazol-4-yl]-5-imino-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile (1380583-84-5) → 5-amino-3-(4-fluorophenyl)-8-imino-7,8-dihydroimidazo[4,5-b]pyrrolo[3,4-d]pyridin-6(3H)-one

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; for 2h; Reflux;

DOI:10.1016/j.tet.2012.04.030

Reference yield: 85.0%

4-[5-amino-1-(4-fluorophenyl)-1H-imidazol-4-yl]-5-imino-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile (1380583-84-5) + orthoformic acid triethyl ester (122-51-0) → 3-(4-fluorophenyl)-8-oxo-7,8-dihydro-3H-imidazo[4,5-d]pyrrolo[3,2-f][1,3]diazepine-9-carbonitrile (1380583-91-4)

Guidance literature:

With sulfuric acid; In acetonitrile; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tet.2012.04.030

upstream raw materials:

5-amino-1-(4-fluorophenyl)-1H-imidazole-4-carbimidoyl cyanide

cyanoacetic acid amide

Downstream raw materials:

3-(4-fluorophenyl)-8-oxo-7,8-dihydro-3H-imidazo[4,5-d]pyrrolo[3,2-f][1,3]diazepine-9-carbonitrile