ethyl 3-(4-methoxyphenyl)-1-{[3-(trifluoromethyl)phenyl]methyl}indole-2-carboxylate

Base Information

Chemical Name:ethyl 3-(4-methoxyphenyl)-1-{[3-(trifluoromethyl)phenyl]methyl}indole-2-carboxylate
CAS No.:412007-80-8
Molecular Formula:C₂₆H₂₂F₃NO₃
Molecular Weight:453.461
Hs Code.:

Synonyms:ethyl 3-(4-methoxyphenyl)-1-{[3-(trifluoromethyl)phenyl]methyl}indole-2-carboxylate

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Chemical Property of ethyl 3-(4-methoxyphenyl)-1-{[3-(trifluoromethyl)phenyl]methyl}indole-2-carboxylate

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Technology Process of ethyl 3-(4-methoxyphenyl)-1-{[3-(trifluoromethyl)phenyl]methyl}indole-2-carboxylate

There total 3 articles about ethyl 3-(4-methoxyphenyl)-1-{[3-(trifluoromethyl)phenyl]methyl}indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 411230-83-6
3-bromo-1-(3-trifluoromethyl-benzyl)-1H-indole-2-carboxylic acid ethyl ester

: 5720-07-0
4-methoxyphenylboronic acid

: 412007-80-8
ethyl 3-(4-methoxyphenyl)-1-{[3-(trifluoromethyl)phenyl]methyl}indole-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; at 85 ℃;
DOI:10.1016/j.bmcl.2006.08.003

Reference yield:

: 3770-50-1,117770-52-2
2-carbethoxyindole

: 412007-80-8
ethyl 3-(4-methoxyphenyl)-1-{[3-(trifluoromethyl)phenyl]methyl}indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NBS / tetrahydrofuran

2: 86 percent / K₂CO₃ / dimethylformamide

3: 86 percent / Pd(PPh₃)4; aq. Na₂CO₃ / ethanol; toluene / 85 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; 3: Suzuki-Miyaura cross-coupling reaction;
DOI:10.1016/j.bmcl.2006.08.003

Reference yield:

: 91348-45-7
3-bromo-1H-indole-2-carboxylic acid ethyl ester

: 412007-80-8
ethyl 3-(4-methoxyphenyl)-1-{[3-(trifluoromethyl)phenyl]methyl}indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / K₂CO₃ / dimethylformamide

2: 86 percent / Pd(PPh₃)4; aq. Na₂CO₃ / ethanol; toluene / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; toluene; 2: Suzuki-Miyaura cross-coupling reaction;
DOI:10.1016/j.bmcl.2006.08.003