ethyl 2'-propioloyl-2,4'-bithiazole-4-carboxylate

Base Information

Chemical Name:ethyl 2'-propioloyl-2,4'-bithiazole-4-carboxylate
CAS No.:1174675-85-4
Molecular Formula:C₁₂H₈N₂O₃S₂
Molecular Weight:292.339
Hs Code.:

Synonyms:ethyl 2'-propioloyl-2,4'-bithiazole-4-carboxylate

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Chemical Property of ethyl 2'-propioloyl-2,4'-bithiazole-4-carboxylate

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Technology Process of ethyl 2'-propioloyl-2,4'-bithiazole-4-carboxylate

There total 1 articles about ethyl 2'-propioloyl-2,4'-bithiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6436-59-5
ethyl 2-methylthiazole-4-carboxylate

: 1174675-85-4
ethyl 2'-propioloyl-2,4'-bithiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium hydroxide / water / 2 h / 70 °C

2: Lawessons reagent / toluene / 2 h / Reflux

3: ethanol / 2 h / Reflux

4: selenium(IV) oxide / acetic acid / 12 h / Reflux

5: tetrahydrofuran / 0.5 h / 20 °C

6: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With Lawessons reagent; selenium(IV) oxide; ammonium hydroxide; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1021/ja110166x

Reference yield:

: 1174675-85-4
ethyl 2'-propioloyl-2,4'-bithiazole-4-carboxylate

: 59979-01-0
thiocillin I

Guidance literature:: Multi-step reaction with 15 steps

1.1: ammonium acetate / 12 h / Reflux

2.1: potassium carbonate / ethanol; dichloromethane

3.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: lithium hydroxide / tetrahydrofuran; water / 2 h

5.1: dmap; triethylamine / dichloromethane / 3 h / Inert atmosphere

6.1: BOP-Cl; triethylamine / acetonitrile / 3 h

7.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / Inert atmosphere

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h

10.1: Dess-Martin periodane / dichloromethane / 2 h

11.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water / 2 h

11.2: pH 2

12.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere

13.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 20 °C

13.2: pH 3

14.1: dichloromethane / 2 h / 20 °C

15.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C

With 1H-imidazole; dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diphenyl phosphoryl azide; BOP-Cl; ammonium acetate; tetrabutyl ammonium fluoride; potassium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 1.1: Bohlmann-Rahtz reaction;
DOI:10.1021/ja110166x