4-n-butylthiobenzamide

Base Information

• Chemical Name: 4-n-butylthiobenzamide
• CAS No.: 1208077-46-6
• Molecular Formula: C₁₁H₁₅NS
• Molecular Weight: 193.313
• Mol file: 1208077-46-6.mol

Synonyms:4-n-butylthiobenzamide

Chemical Property of 4-n-butylthiobenzamide

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

4-Butylthiobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-n-butylthiobenzamide

There total 3 articles about 4-n-butylthiobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-n-butylbenzamide (107377-07-1) → 4-n-butylthiobenzamide (1208077-46-6)

Guidance literature:

With Lawessons reagent; In tetrahydrofuran; at 23 ℃; for 1h;

DOI:10.1016/j.bmc.2011.09.031

Reference yield:

4-butyl benzoic acid (20651-71-2) → 4-n-butylthiobenzamide (1208077-46-6)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 2 h / Reflux

2: ammonium hydroxide / water / 0 - 23 °C

3: Lawessons reagent / tetrahydrofuran

With Lawessons reagent; ammonium hydroxide; thionyl chloride; In tetrahydrofuran; water;

DOI:10.1021/jm401905m

Reference yield:

4-butylbenzoyl chloride (28788-62-7) → 4-n-butylthiobenzamide (1208077-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / water / 0 - 23 °C

2: Lawessons reagent / tetrahydrofuran

With Lawessons reagent; ammonium hydroxide; In tetrahydrofuran; water;

DOI:10.1021/jm401905m

upstream raw materials:

4-n-butylbenzamide

4-butyl benzoic acid

4-butylbenzoyl chloride

Downstream raw materials:

2-(1-(2-(4-butylphenyl)-4-methylthiazol-5-yl)ethylidene)hydrazinecarboximidamide

3,5-bis(4-butylphenyl)-1,2,4-thiadiazole

1-(2-(4-butylphenyl)-4-methylthiazol-5-yl)ethanone

methyl 2-(4-butylphenyl)-4-methylthiazole-5-carboxylate

Refernces

• 1、 -. "ANTIMICROBIAL SUBSTITUTED THIAZOLES AND METHODS OF USE". Paragraph 0049. . Retrieved 2014/05/08.