2-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Base Information

• Chemical Name: 2-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• CAS No.: 1262971-70-9
• Molecular Formula: C₂₀H₂₁NO₆
• Molecular Weight: 371.39

Synonyms:2-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Chemical Property of 2-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Chemical Property:

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Technology Process of 2-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

There total 1 articles about 2-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride (41994-51-8) + 3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → 2-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (1262971-70-9)

Guidance literature:

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride; With sodium hydroxide; In acetone; at 20 ℃;

3,4,5-Trimethoxybenzoyl chloride; With sodium hydroxide; In acetone; at 20 ℃; pH=> 10;

With hydrogenchloride; In water; pH=5 - 6;

DOI:10.1016/j.bmc.2010.11.030

Reference yield: 51.0%

2-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (1262971-70-9) + dimethyl acetylenedicarboxylate (762-42-5) → 3-(3,4,5-trimethoxyphenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-dicarboxylic acid dimethyl ester (1262971-78-7)

Guidance literature:

With acetic anhydride; at 65 ℃; for 1.5h;

DOI:10.1016/j.bmc.2010.11.030

upstream raw materials:

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride

3,4,5-Trimethoxybenzoyl chloride

Downstream raw materials:

3-(3,4,5-trimethoxyphenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-dicarboxylic acid dimethyl ester

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