1-(3'-methylphenyl)-1,2-dihydroxyethane

Base Information

• Chemical Name: 1-(3'-methylphenyl)-1,2-dihydroxyethane
• CAS No.: 78649-50-0
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.193
• Mol file: 78649-50-0.mol

Synonyms:1-(3'-methylphenyl)-1,2-dihydroxyethane

Chemical Property of 1-(3'-methylphenyl)-1,2-dihydroxyethane

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3'-methylphenyl)-1,2-dihydroxyethane

There total 10 articles about 1-(3'-methylphenyl)-1,2-dihydroxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-methylstyrene (100-80-1) → 1-(3'-methylphenyl)-1,2-dihydroxyethane (78649-50-0)

Guidance literature:

3-methylstyrene; With water; cyclopropane-1,1-dicarbonyl peroxide; In chloroform; at 40 ℃; for 24h;

With water; sodium hydroxide; at 60 ℃; for 4h;

DOI:10.1021/ja1066674

Reference yield: 70.0%

1-ethynyl-3-methyl-benzene (766-82-5) → 1-(3'-methylphenyl)-1,2-dihydroxyethane (78649-50-0)

Guidance literature:

1-ethynyl-3-methyl-benzene; With borane-ammonia complex; In tetrahydrofuran; at 90 ℃; for 1h; Reflux;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2018.01.041

Reference yield: 65.0%

3-methylstyrene (100-80-1) + spirocyclobutylmalonoyl peroxide (34867-87-3) → 1-(3'-methylphenyl)-1,2-dihydroxyethane (78649-50-0)

Guidance literature:

3-methylstyrene; spirocyclobutylmalonoyl peroxide; With water; In chloroform; at 40 ℃;

With water; sodium hydroxide; In chloroform; at 40 ℃; for 18h;

DOI:10.1021/jo202084w

upstream raw materials:

3-methylstyrene oxide

3-methylstyrene

spirocyclobutylmalonoyl peroxide

m-tolyl aldehyde

Downstream raw materials:

6-chloro-3-(3-methyl-benzyl)-1,1-dioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

3-(3-methyl-benzyl)-1,1-dioxo-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

6-bromo-3-(3-methyl-benzyl)-1,1-dioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

2-phenyl-4-m-tolyl-[1,3]dioxolane