2-(((3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl)oxy)-5-iodopyridine

Base Information

Chemical Name:2-(((3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl)oxy)-5-iodopyridine
CAS No.:1610036-16-2
Molecular Formula:C₁₉H₂₂FIN₂O₂
Molecular Weight:456.299
Hs Code.:

Synonyms:2-(((3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl)oxy)-5-iodopyridine

Suppliers and Price of 2-(((3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl)oxy)-5-iodopyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(((3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl)oxy)-5-iodopyridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(((3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl)oxy)-5-iodopyridine

There total 6 articles about 2-(((3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl)oxy)-5-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 13472-79-2
5-iodo-pyridin-2-ol

: (3,4-cis)-1-(5-ethoxy-2-fluorophenyl)-3-ethylpiperidin-4-ol

: 1610036-16-2
2-(((3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl)oxy)-5-iodopyridine

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; for 1.65h; Sonication;

Reference yield:

: 34737-89-8
1-Benzyl-3-methyl-4-piperidon

: 1610036-16-2
2-(((3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl)oxy)-5-iodopyridine

Guidance literature:: Multi-step reaction with 4 steps

1: methyl iodide / acetone / 20 °C

2: potassium carbonate / water; ethanol / 95 °C

3: L-Selectride / tetrahydrofuran / 1 h / -78 °C

4: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 1.65 h / Sonication

With tributylphosphine; L-Selectride; potassium carbonate; 1,1'-azodicarbonyl-dipiperidine; methyl iodide; In tetrahydrofuran; ethanol; water; acetone; toluene;

Reference yield:

: 1190075-01-4
5-ethoxy-2-fluoroaniline

: 1610036-16-2
2-(((3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl)oxy)-5-iodopyridine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / water; ethanol / 95 °C

2: L-Selectride / tetrahydrofuran / 1 h / -78 °C

3: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 1.65 h / Sonication

With tributylphosphine; L-Selectride; potassium carbonate; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; water; toluene;