cis-(4R,6S)-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>-2,2-dimethyl-1,3-dioxane-4-acetic acid

Base Information

Chemical Name:cis-(4R,6S)-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>-2,2-dimethyl-1,3-dioxane-4-acetic acid
CAS No.:118845-89-9
Molecular Formula:C₂₆H₂₆F₂N₄O₄
Molecular Weight:496.514
Hs Code.:

Synonyms:cis-(4R,6S)-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>-2,2-dimethyl-1,3-dioxane-4-acetic acid

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Chemical Property of cis-(4R,6S)-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>-2,2-dimethyl-1,3-dioxane-4-acetic acid

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Technology Process of cis-(4R,6S)-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>-2,2-dimethyl-1,3-dioxane-4-acetic acid

There total 9 articles about cis-(4R,6S)-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>-2,2-dimethyl-1,3-dioxane-4-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.6%

: phosphonate anion

: 123185-91-1
cis-(4R,6S)-2,2-dimethyl-6-formyl-1,3-dioxane-4-acetic acid

: 118845-72-0
dimethyl <3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propen-1-yl>phosphonate

: 118845-89-9
cis-(4R,6S)-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>-2,2-dimethyl-1,3-dioxane-4-acetic acid

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

: 123185-91-1
cis-(4R,6S)-2,2-dimethyl-6-formyl-1,3-dioxane-4-acetic acid

: 118845-89-9
cis-(4R,6S)-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>-2,2-dimethyl-1,3-dioxane-4-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) a) -78 deg C, 30 min, b) RT, 16 h

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1021/jm00173a013

Reference yield:

: 109519-27-9,109583-02-0,118918-07-3,125517-60-4,130273-26-6
methyl (3S^*,5R^*)-3,5-isopropylidenedioxy-7-phenyl-6-heptenoate

: 118845-89-9
cis-(4R,6S)-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>-2,2-dimethyl-1,3-dioxane-4-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / 1 N NaOH / methanol / 0.75 h / Heating

3: 1.) O₃, 2.) Me₂S / CH₂Cl₂ / 1.) -78 deg C, 2.) RT, 16 h

4: n-BuLi / tetrahydrofuran; hexane / -78 °C

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) a) -78 deg C, 30 min, b) RT, 16 h

With sodium hydroxide; n-butyllithium; dimethylsulfide; ozone; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jm00173a013