5-(2-amino-4-methoxycarbonylphenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Base Information

Chemical Name:5-(2-amino-4-methoxycarbonylphenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile
CAS No.:1375262-94-4
Molecular Formula:C₂₀H₂₆N₄O₃
Molecular Weight:370.451
Hs Code.:

Synonyms:5-(2-amino-4-methoxycarbonylphenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

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Chemical Property of 5-(2-amino-4-methoxycarbonylphenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Chemical Property:

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Technology Process of 5-(2-amino-4-methoxycarbonylphenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

There total 11 articles about 5-(2-amino-4-methoxycarbonylphenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 380430-55-7
(2-amino-4-(methoxycarbonyl)phenyl)boronic acid hydrochloride salt

: 1375262-96-6
2-butyl-1-(2-hydroxy-2-methylpropyl)-5-iodo-1H-imidazole-4-carbonitrile

: 1399983-82-4
2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

: 1375262-94-4
5-(2-amino-4-methoxycarbonylphenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 100 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ml300079e

Reference yield:

: 380430-55-7
(2-amino-4-(methoxycarbonyl)phenyl)boronic acid hydrochloride salt

: 1375262-96-6
2-butyl-1-(2-hydroxy-2-methylpropyl)-5-iodo-1H-imidazole-4-carbonitrile

: 1375262-94-4
5-(2-amino-4-methoxycarbonylphenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 100 ℃; for 21h;

Reference yield:

: 1375262-90-0
5-amino-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

: 1375262-94-4
5-(2-amino-4-methoxycarbonylphenyl)-2-butyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: diiodomethane; isopentyl nitrite / chloroform / 0.83 h / 80 °C

2: palladium diacetate; triphenylphosphine; sodium carbonate / 1,2-dimethoxyethane; water / 21 h / 100 °C

With diiodomethane; palladium diacetate; sodium carbonate; triphenylphosphine; isopentyl nitrite; In 1,2-dimethoxyethane; chloroform; water;