diethyl 6,6'-((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(4-bromopicolinate)

Base Information

• Chemical Name: diethyl 6,6'-((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(4-bromopicolinate)
• CAS No.: 1425509-99-4
• Molecular Formula: C₄₁H₄₄Br₂N₆O₈
• Molecular Weight: 908.644
• Mol file: 1425509-99-4.mol

Synonyms:diethyl 6,6'-((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(4-bromopicolinate)

Chemical Property of diethyl 6,6'-((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(4-bromopicolinate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 6,6'-((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(4-bromopicolinate)

There total 5 articles about diethyl 6,6'-((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(4-bromopicolinate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-Ethynylaniline (14235-81-5) + diethyl 6,6'-((((4-iodopyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(4-bromopicolinate) (1425509-98-3) → diethyl 6,6'-((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(4-bromopicolinate) (1425509-99-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

2,6-bis(hydroxymethyl)-4-iodopyridine (120491-91-0) → diethyl 6,6'-((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(4-bromopicolinate) (1425509-99-4)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus tribromide / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 4 h / 55 - 60 °C

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / dichloromethane / 3 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; phosphorus tribromide; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

diethyl 4-iodo-2,6-pyridinedicarboxylate (120491-90-9) → diethyl 6,6'-((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(4-bromopicolinate) (1425509-99-4)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol; sodium tetrahydroborate / ethanol / 1.5 h / Reflux

2: phosphorus tribromide / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

3: potassium carbonate / acetonitrile / 4 h / 55 - 60 °C

4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / dichloromethane / 3 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; ethanol; phosphorus tribromide; potassium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

2,6-bis(hydroxymethyl)-4-iodopyridine

diethyl 4-iodo-2,6-pyridinedicarboxylate

4-Ethynylaniline

diethyl 6,6'-((((4-iodopyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(4-bromopicolinate)

Downstream raw materials:

tetra-tert-butyl 2,2',2,2'-((((6,6'-((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(2-(ethoxycarbonyl)pyridine-6,4-diyl))bis(ethyne-2,1-diyl))bis(benzene-5,3,1-triyl))tetrakis(oxy))tetraacetate

tetraethyl 2,2',2,2'-((((6,6'-((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))bis(2-(ethoxycarbonyl)pyridine-6,4-diyl))bis(ethyne-2,1-diyl))bis(benzene-4,2,1-triyl))tetrakis(oxy))tetraacetate