Technology Process of bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-dimethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)
There total 3 articles about bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-dimethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,3,5,7-tetramethyl-2,6-bis(2-methoxycarbonylethyl)-8-[4-(N,N-dimethylamino)phenyl]-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene;
With
sodium hydroxide;
In
1,4-dioxane; methanol; water;
at 40 ℃;
for 0.833333h;
With
hydrogenchloride;
In
1,4-dioxane; methanol; water;
DOI:10.1039/c1cc12947c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
1.2: 1 h / 20 °C / Inert atmosphere
1.3: 2 h / 20 °C / Inert atmosphere
2.1: sodium hydroxide / 1,4-dioxane; methanol; water / 0.83 h / 40 °C
With
trifluoroacetic acid; sodium hydroxide;
In
1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1039/c1cc12947c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
1.2: 1 h / 20 °C / Inert atmosphere
1.3: 2 h / 20 °C / Inert atmosphere
2.1: sodium hydroxide / 1,4-dioxane; methanol; water / 0.83 h / 40 °C
With
trifluoroacetic acid; sodium hydroxide;
In
1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1039/c1cc12947c