tert-Butyl-((2S,4R)-2-{2-[cyclohexyl-(4-fluoro-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

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Chemical Name:tert-Butyl-((2S,4R)-2-{2-[cyclohexyl-(4-fluoro-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane
CAS No.:110723-93-8
Molecular Formula:C₄₄H₅₅FO₄Si
Molecular Weight:695.002
Hs Code.:

Synonyms:tert-Butyl-((2S,4R)-2-{2-[cyclohexyl-(4-fluoro-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

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Chemical Property of tert-Butyl-((2S,4R)-2-{2-[cyclohexyl-(4-fluoro-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

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Technology Process of tert-Butyl-((2S,4R)-2-{2-[cyclohexyl-(4-fluoro-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

There total 9 articles about tert-Butyl-((2S,4R)-2-{2-[cyclohexyl-(4-fluoro-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931-51-1
cyclohexylmagnesiumchloride

: 110723-93-8
tert-Butyl-((2S,4R)-2-{2-[cyclohexyl-(4-fluoro-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / diethyl ether / 3 h / 20 °C

2: 89 percent / H₂ / 10percent Pd/C / methanol / 5 h / 25 °C / 750.06 Torr

3: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

With hydrogen; potassium carbonate; hydroquinone; palladium on activated charcoal; In methanol; diethyl ether; dimethyl sulfoxide;
DOI:10.1021/jm00114a004

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 110723-93-8
tert-Butyl-((2S,4R)-2-{2-[cyclohexyl-(4-fluoro-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH / H₂O / 0.5 h

2: AlCl₃ / 2 h / 150 °C

3: 70 percent / diethyl ether / 3 h / 20 °C

4: 89 percent / H₂ / 10percent Pd/C / methanol / 5 h / 25 °C / 750.06 Torr

5: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

With sodium hydroxide; aluminium trichloride; hydrogen; potassium carbonate; hydroquinone; palladium on activated charcoal; In methanol; diethyl ether; water; dimethyl sulfoxide;
DOI:10.1021/jm00114a004

Reference yield:

: 650621-58-2
4-Fluoro-benzoic acid 2,4-dimethyl-phenyl ester

: 110723-93-8
tert-Butyl-((2S,4R)-2-{2-[cyclohexyl-(4-fluoro-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: AlCl₃ / 2 h / 150 °C

2: 70 percent / diethyl ether / 3 h / 20 °C

3: 89 percent / H₂ / 10percent Pd/C / methanol / 5 h / 25 °C / 750.06 Torr

4: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

With aluminium trichloride; hydrogen; potassium carbonate; hydroquinone; palladium on activated charcoal; In methanol; diethyl ether; dimethyl sulfoxide;
DOI:10.1021/jm00114a004