2-(5-(2-(Isopropylamino)ethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one

Base Information

Chemical Name:2-(5-(2-(Isopropylamino)ethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one
CAS No.:1610372-92-3
Molecular Formula:C₂₆H₂₈N₄O₄S
Molecular Weight:492.599
Hs Code.:

Synonyms:2-(5-(2-(Isopropylamino)ethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one

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Chemical Property of 2-(5-(2-(Isopropylamino)ethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one

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Technology Process of 2-(5-(2-(Isopropylamino)ethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one

There total 10 articles about 2-(5-(2-(Isopropylamino)ethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1610373-99-3
2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate

: 75-31-0
isopropylamine

: 1610372-92-3
2-(5-(2-(Isopropylamino)ethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one

Guidance literature:: With sodium iodide; In dimethyl sulfoxide; at 60 ℃; for 4h; Sealed tube;

Reference yield:

: 168015-04-1
2-bromo-6-(hydroxymethyl)pyridin-3-ol

: 1610372-92-3
2-(5-(2-(Isopropylamino)ethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 20 h / 60 °C / Inert atmosphere

2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid; sodium hydrogen sulfate / N,N-dimethyl acetamide / 20 h / 120 °C

5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6.1: sodium iodide / dimethyl sulfoxide / 4 h / 60 °C / Sealed tube

With sodium hydrogen sulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium iodide; In ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1610372-92-3
2-(5-(2-(Isopropylamino)ethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide; ethylenediaminetetraacetic acid disodium salt dihydrate / water / 5 h / 90 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 20 h / 60 °C / Inert atmosphere

3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid; sodium hydrogen sulfate / N,N-dimethyl acetamide / 20 h / 120 °C

6.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

7.1: sodium iodide / dimethyl sulfoxide / 4 h / 60 °C / Sealed tube

With sodium hydrogen sulfate; ethylenediaminetetraacetic acid disodium salt dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium iodide; potassium hydroxide; In ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;