2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate

Base Information

Chemical Name:2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate
CAS No.:1610373-99-3
Molecular Formula:C₂₄H₂₃N₃O₇S₂
Molecular Weight:529.595
Hs Code.:

Synonyms:2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate

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Chemical Property of 2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate

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Technology Process of 2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate

There total 9 articles about 2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1610372-86-5
2-(5-(2-hydroxyethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one

: 124-63-0
methanesulfonyl chloride

: 1610373-99-3
2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 168015-04-1
2-bromo-6-(hydroxymethyl)pyridin-3-ol

: 1610373-99-3
2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 20 h / 60 °C / Inert atmosphere

2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid; sodium hydrogen sulfate / N,N-dimethyl acetamide / 20 h / 120 °C

5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With sodium hydrogen sulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1610373-99-3
2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; ethylenediaminetetraacetic acid disodium salt dihydrate / water / 5 h / 90 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 20 h / 60 °C / Inert atmosphere

3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid; sodium hydrogen sulfate / N,N-dimethyl acetamide / 20 h / 120 °C

6.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With sodium hydrogen sulfate; ethylenediaminetetraacetic acid disodium salt dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; In ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;