7-cyano-6-{[4-(tert-butyl)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine

Base Information

Chemical Name:7-cyano-6-{[4-(tert-butyl)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine
CAS No.:1354785-39-9
Molecular Formula:C₂₄H₂₁F₃N₄O₂S
Molecular Weight:486.518
Hs Code.:

Synonyms:7-cyano-6-{[4-(tert-butyl)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine

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Chemical Property of 7-cyano-6-{[4-(tert-butyl)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine

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Technology Process of 7-cyano-6-{[4-(tert-butyl)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine

There total 5 articles about 7-cyano-6-{[4-(tert-butyl)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1034047-04-5,1339942-87-8
6-[(4-tert-butylphenyl)sulfonyl]-7-chloro-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine

: 1354785-39-9
7-cyano-6-{[4-(tert-butyl)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 150 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/ml200304j

Reference yield:

: 1039715-36-0
C₁₃H₇ClF₃N₃O

: 1354785-39-9
7-cyano-6-{[4-(tert-butyl)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: pyridine; dmap / dichloromethane / 12 h / 0 - 20 °C

3: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; borane-THF; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200304j

Reference yield:

: 59483-54-4
3-chloro-2-nitro-aniline

: 1354785-39-9
7-cyano-6-{[4-(tert-butyl)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1: platinum(IV) oxide; hydrogen / ethanol / 4 h / 760.05 Torr

2: 2-Butoxyethanol / 22 h / 150 °C

3: borane-THF / tetrahydrofuran / 0 - 20 °C

4: pyridine; dmap / dichloromethane / 12 h / 0 - 20 °C

5: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; dmap; platinum(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; borane-THF; hydrogen; In tetrahydrofuran; ethanol; dichloromethane; 2-Butoxyethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200304j