{3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b]-[1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}methanol

Base Information

Chemical Name:{3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b]-[1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}methanol
CAS No.:1034044-54-6
Molecular Formula:C₂₆H₂₄F₃N₅O₄S
Molecular Weight:559.569
Hs Code.:

{3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b]-[1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}methanol

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Chemical Property of {3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b]-[1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}methanol

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Technology Process of {3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b]-[1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}methanol

There total 25 articles about {3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b]-[1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1039715-74-6
C₃₃H₃₀F₃N₅O₄S

: 1034044-54-6,1034153-09-7,1034153-11-1
{3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b]-[1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}methanol

Guidance literature:: C₃₃H₃₀F₃N₅O₄S; With methanesulfonic acid; In chloroform; for 0.25h;

With sodium hydrogencarbonate;

Reference yield:

: 1354785-39-9
7-cyano-6-{[4-(tert-butyl)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine

: 1034044-54-6,1034153-09-7,1034153-11-1
{3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b]-[1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine; potassium carbonate / ethanol; water / 0.33 h / 120 °C / Microwave irradiation

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.5 h

2.2: 70 °C

3.1: methanesulfonic acid / chloroform / 0.25 h

With methanesulfonic acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydroxylamine; potassium carbonate; triethylamine; In ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200304j

Reference yield:

: 1039715-36-0
C₁₃H₇ClF₃N₃O

: 1034044-54-6,1034153-09-7,1034153-11-1
{3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b]-[1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 0 - 20 °C

2.1: pyridine; dmap / dichloromethane / 12 h / 0 - 20 °C

3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

4.1: hydroxylamine; potassium carbonate / ethanol; water / 0.33 h / 120 °C / Microwave irradiation

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.5 h

5.2: 70 °C

6.1: methanesulfonic acid / chloroform / 0.25 h

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; borane-THF; methanesulfonic acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydroxylamine; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200304j