diethyl 2-[4-({(3S,5S,6R)-2-oxo-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]propane-1,3-dioate

Base Information

Chemical Name:diethyl 2-[4-({(3S,5S,6R)-2-oxo-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]propane-1,3-dioate
CAS No.:863719-47-5
Molecular Formula:C₃₈H₃₇NO₈
Molecular Weight:635.714
Hs Code.:

Synonyms:diethyl 2-[4-({(3S,5S,6R)-2-oxo-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]propane-1,3-dioate

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Chemical Property of diethyl 2-[4-({(3S,5S,6R)-2-oxo-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]propane-1,3-dioate

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Technology Process of diethyl 2-[4-({(3S,5S,6R)-2-oxo-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]propane-1,3-dioate

There total 6 articles about diethyl 2-[4-({(3S,5S,6R)-2-oxo-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]propane-1,3-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 863719-40-8
diethyl 2-[4-(bromomethyl)phenyl]propane-1,3-dioate

: 100516-54-9,335159-14-3
(5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 863719-47-5
diethyl 2-[4-({(3S,5S,6R)-2-oxo-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]propane-1,3-dioate

Guidance literature:: (5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 0.5h;

diethyl 2-[4-(bromomethyl)phenyl]propane-1,3-dioate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 20 ℃; for 1h;
DOI:10.1021/jm050154v

Reference yield:

: 624-31-7
4-tolyl iodide

: 863719-47-5
diethyl 2-[4-({(3S,5S,6R)-2-oxo-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]propane-1,3-dioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dioxane / 0.5 h / 20 °C

1.2: CuBr / dioxane / 1 h / 95 - 98 °C

1.3: 35 percent / HMPA / dioxane / 2 h

2.1: 78 percent Turnov_. / N-bromosuccinimide; AIBN / CH₂Cl₂ / 2 h / 85 °C

3.1: LHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / -78 °C

3.2: 14 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/jm050154v

Reference yield:

: 29148-27-4
diethyl 2-(4-methylphenyl)propane-1,3-dioate

: 863719-47-5
diethyl 2-[4-({(3S,5S,6R)-2-oxo-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]propane-1,3-dioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 78 percent Turnov_. / N-bromosuccinimide; AIBN / CH₂Cl₂ / 2 h / 85 °C

2.1: LHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / -78 °C

2.2: 14 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/jm050154v