tert-butyl 2-(5-cyano-2-fluorophenyl)-2-hydroxypyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-(5-cyano-2-fluorophenyl)-2-hydroxypyrrolidine-1-carboxylate
CAS No.:1364890-41-4
Molecular Formula:C₁₆H₁₉FN₂O₃
Molecular Weight:306.337
Hs Code.:

Synonyms:tert-butyl 2-(5-cyano-2-fluorophenyl)-2-hydroxypyrrolidine-1-carboxylate

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Chemical Property of tert-butyl 2-(5-cyano-2-fluorophenyl)-2-hydroxypyrrolidine-1-carboxylate

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Technology Process of tert-butyl 2-(5-cyano-2-fluorophenyl)-2-hydroxypyrrolidine-1-carboxylate

There total 1 articles about tert-butyl 2-(5-cyano-2-fluorophenyl)-2-hydroxypyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85909-08-6
tert-butyl 2-oxopyrrolidine-1-carboxylate

: 79630-23-2
3-bromo-4-fluorobenzonitrile

: 1364890-41-4
tert-butyl 2-(5-cyano-2-fluorophenyl)-2-hydroxypyrrolidine-1-carboxylate

Guidance literature:: 3-bromo-4-fluorobenzonitrile; With isopropylmagnesium chloride; In tetrahydrofuran; at -78 - -30 ℃; for 1h;

tert-butyl 2-oxopyrrolidine-1-carboxylate; In tetrahydrofuran; at -78 - 0 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; water; for 0.333333h;

Reference yield:

: 1364890-41-4
tert-butyl 2-(5-cyano-2-fluorophenyl)-2-hydroxypyrrolidine-1-carboxylate

: 1270415-33-2
4-fluoro-3-(pyrrolidin-2-yl)benzonitrile

Guidance literature:: tert-butyl 2-(5-cyano-2-fluorophenyl)-2-hydroxypyrrolidine-1-carboxylate; With hydrogenchloride; In methanol; diethyl ether;

With methanol; sodium tetrahydroborate; at 20 ℃; for 2h; Inert atmosphere;

With sodium hydrogencarbonate; In methanol; water; pH=8 - 9;