5-(2-ethoxy-5-(methylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Base Information

Chemical Name:5-(2-ethoxy-5-(methylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
CAS No.:459834-16-3
Molecular Formula:C₁₈H₂₂N₄O₄S
Molecular Weight:390.463
Hs Code.:

Synonyms:5-(2-ethoxy-5-(methylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Suppliers and Price of 5-(2-ethoxy-5-(methylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2-ethoxy-5-(methylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Chemical Property:

Purity/Quality:: 95+%HPLC ^*data from raw suppliers

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Technology Process of 5-(2-ethoxy-5-(methylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

There total 4 articles about 5-(2-ethoxy-5-(methylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1491216-01-3
5-(2-ethoxy-5-iodophenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

: 74-88-4
methyl iodide

: 459834-16-3
5-(2-ethoxy-5-(methylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Guidance literature:: 5-(2-ethoxy-5-iodophenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one; With 1,10-Phenanthroline; potassium pyrosulfite; tetraethylammonium bromide; sodium formate; palladium diacetate; triphenylphosphine; In dimethyl sulfoxide; at 70 ℃; for 2h; Inert atmosphere; Microwave irradiation;

methyl iodide; In dimethyl sulfoxide; at 23 ℃; for 20h; chemoselective reaction; Inert atmosphere;
DOI:10.1021/ol403072r

Reference yield: 54.0%

: 147676-70-8
5-(5-bromo-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one

: 74-88-4
methyl iodide

: 459834-16-3
5-(2-ethoxy-5-(methylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Guidance literature:: 5-(5-bromo-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one; With 1,10-Phenanthroline; potassium pyrosulfite; tetraethylammonium bromide; sodium formate; palladium diacetate; triphenylphosphine; In dimethyl sulfoxide; at 70 ℃; for 20h; Inert atmosphere; Microwave irradiation;

methyl iodide; In dimethyl sulfoxide; at 23 ℃; for 20h; chemoselective reaction; Inert atmosphere;
DOI:10.1021/ol403072r