Troc-(S)-Thr[Boc-(S)-Phs(Bn)-(S)-Phe-(S)-NMe-Tyr(TBS)-(S)-Ile]-(S)-Phe-OAllyl

Base Information

Chemical Name:Troc-(S)-Thr[Boc-(S)-Phs(Bn)-(S)-Phe-(S)-NMe-Tyr(TBS)-(S)-Ile]-(S)-Phe-OAllyl
CAS No.:370867-52-0
Molecular Formula:C₆₇H₉₁Cl₃N₆O₁₄Si
Molecular Weight:1338.94
Hs Code.:

Synonyms:Troc-(S)-Thr[Boc-(S)-Phs(Bn)-(S)-Phe-(S)-NMe-Tyr(TBS)-(S)-Ile]-(S)-Phe-OAllyl

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Chemical Property of Troc-(S)-Thr[Boc-(S)-Phs(Bn)-(S)-Phe-(S)-NMe-Tyr(TBS)-(S)-Ile]-(S)-Phe-OAllyl

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Technology Process of Troc-(S)-Thr[Boc-(S)-Phs(Bn)-(S)-Phe-(S)-NMe-Tyr(TBS)-(S)-Ile]-(S)-Phe-OAllyl

There total 35 articles about Troc-(S)-Thr[Boc-(S)-Phs(Bn)-(S)-Phe-(S)-NMe-Tyr(TBS)-(S)-Ile]-(S)-Phe-OAllyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 848780-48-3
Troc-(S)-Thr[Boc-(S)-Phs(Bn)-(S)-Phe-(S)-NMe-Tyr-(S)-Ile]-(S)-Phe-OAllyl

: 370867-52-0
Troc-(S)-Thr[Boc-(S)-Phs(Bn)-(S)-Phe-(S)-NMe-Tyr(TBS)-(S)-Ile]-(S)-Phe-OAllyl

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 13h;
DOI:10.1016/j.tet.2004.12.009

Reference yield:

: 30924-93-7
Boc-Glu-OBn

: 370867-52-0
Troc-(S)-Thr[Boc-(S)-Phs(Bn)-(S)-Phe-(S)-NMe-Tyr(TBS)-(S)-Ile]-(S)-Phe-OAllyl

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / tetrahydrofuran / 1 h / -10 °C

2: 2.86 g / NaBH₄ / tetrahydrofuran; H₂O / 3 h / -10 - 20 °C

3: 82 percent / Ag₂O / diethyl ether / 14 h

4: LiOH / tetrahydrofuran; H₂O / 12 h / 20 °C

5: 60 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 19 h / 0 - 20 °C

6: LiOH / tetrahydrofuran; H₂O / 2 h / 0 - 20 °C

7: 77 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 15 h / 0 - 20 °C

8: 75 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

With 1H-imidazole; lithium hydroxide; sodium tetrahydroborate; diethyl cyanophosphonate; triethylamine; silver(l) oxide; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.12.009

Reference yield:

: 91229-97-9
(S)-2-[N-(tert-butoxycarbonyl)amino]-5-hydroxypentanoic acid benzyl ester

: 370867-52-0
Troc-(S)-Thr[Boc-(S)-Phs(Bn)-(S)-Phe-(S)-NMe-Tyr(TBS)-(S)-Ile]-(S)-Phe-OAllyl

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / Ag₂O / diethyl ether / 14 h

2: LiOH / tetrahydrofuran; H₂O / 12 h / 20 °C

3: 60 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 19 h / 0 - 20 °C

4: LiOH / tetrahydrofuran; H₂O / 2 h / 0 - 20 °C

5: 77 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 15 h / 0 - 20 °C

6: 75 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

With 1H-imidazole; lithium hydroxide; diethyl cyanophosphonate; triethylamine; silver(l) oxide; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.12.009