C₂₁H₂₆N₄O₄

Base Information

• Chemical Name: C₂₁H₂₆N₄O₄
• CAS No.: 1422363-56-1
• Molecular Formula: C₂₁H₂₆N₄O₄
• Molecular Weight: 398.462
• Mol file: 1422363-56-1.mol

Synonyms:C₂₁H₂₆N₄O₄

Chemical Property of C₂₁H₂₆N₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₆N₄O₄

There total 11 articles about C₂₁H₂₆N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

C28H34N4O6 (1422363-55-0) → C21H26N4O4 (1422363-56-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; In dichloromethane; at 20 ℃; for 6h; Darkness;

DOI:10.1039/c2cc38382a

Reference yield:

N-allyloxycarbonyl α-allyl-L-glutamate (91871-28-2) → C21H26N4O4 (1422363-56-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 20 °C / Inert atmosphere

2.1: phosphorus tribromide / tetrahydrofuran / 2 h / 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

3.2: 4 h / 0 °C

4.1: dichloromethane / 20 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / Reflux; Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane / dichloromethane / 6 h / 20 °C / Darkness

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; phosphorus tribromide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1039/c2cc38382a

Reference yield:

allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate (1422363-48-1) → C21H26N4O4 (1422363-56-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: phosphorus tribromide / tetrahydrofuran / 2 h / 0 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

2.2: 4 h / 0 °C

3.1: dichloromethane / 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / Reflux; Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane / dichloromethane / 6 h / 20 °C / Darkness

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; phosphorus tribromide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1039/c2cc38382a

upstream raw materials:

C₁₆H₂₅NO₆

N-allyloxycarbonyl α-allyl-L-glutamate

Fmoc-Glu(OtBu)-OH

allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate