Technology Process of 5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
There total 11 articles about 5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
5%-palladium/activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 65h;
DOI:10.1002/ejoc.201700387
- Guidance literature:
-
Multi-step reaction with 10 steps
1: di-tert-butyl dicarbonate; zinc diacetate / dichloromethane / 36 h / Reflux
2: potassium bromide; Oxone / water; ethyl acetate / 20 h / 0 °C
3: toluene-4-sulfonic acid / 20 h / 20 °C
4: N,N-dimethyl-formamide / 9 h / 135 °C
5: potassium carbonate / methanol / 3 h / 20 °C
6: triethylamine / dichloromethane / 4 h / 0 - 20 °C
7: dimethyl sulfoxide / 40 h / 30 °C
8: nickel; potassium borohydride / ethanol / 1 h / 55 °C / Inert atmosphere
9: Trimethylacetic acid / tetrahydrofuran; toluene; n-heptane / 50 h / Reflux; Inert atmosphere
10: 5%-palladium/activated carbon; hydrogen / methanol / 65 h / 20 °C
With
Oxone; potassium borohydride; di-tert-butyl dicarbonate; 5%-palladium/activated carbon; zinc diacetate; hydrogen; nickel; potassium carbonate; toluene-4-sulfonic acid; triethylamine; potassium bromide; Trimethylacetic acid;
In
tetrahydrofuran; methanol; ethanol; n-heptane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1002/ejoc.201700387
- Guidance literature:
-
Multi-step reaction with 9 steps
1: potassium bromide; Oxone / water; ethyl acetate / 20 h / 0 °C
2: toluene-4-sulfonic acid / 20 h / 20 °C
3: N,N-dimethyl-formamide / 9 h / 135 °C
4: potassium carbonate / methanol / 3 h / 20 °C
5: triethylamine / dichloromethane / 4 h / 0 - 20 °C
6: dimethyl sulfoxide / 40 h / 30 °C
7: nickel; potassium borohydride / ethanol / 1 h / 55 °C / Inert atmosphere
8: Trimethylacetic acid / tetrahydrofuran; toluene; n-heptane / 50 h / Reflux; Inert atmosphere
9: 5%-palladium/activated carbon; hydrogen / methanol / 65 h / 20 °C
With
Oxone; potassium borohydride; 5%-palladium/activated carbon; hydrogen; nickel; potassium carbonate; toluene-4-sulfonic acid; triethylamine; potassium bromide; Trimethylacetic acid;
In
tetrahydrofuran; methanol; ethanol; n-heptane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1002/ejoc.201700387