N-(tri-(isopropyl)silyloxycarbonyl)-2-(4-benzyloxy-3-methoxyphenyl)-4,5-methylenedioxybenzylamine

Base Information

Chemical Name:N-(tri-(isopropyl)silyloxycarbonyl)-2-(4-benzyloxy-3-methoxyphenyl)-4,5-methylenedioxybenzylamine
CAS No.:438036-72-7
Molecular Formula:C₃₂H₄₁NO₆Si
Molecular Weight:563.766
Hs Code.:

Synonyms:N-(tri-(isopropyl)silyloxycarbonyl)-2-(4-benzyloxy-3-methoxyphenyl)-4,5-methylenedioxybenzylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(tri-(isopropyl)silyloxycarbonyl)-2-(4-benzyloxy-3-methoxyphenyl)-4,5-methylenedioxybenzylamine

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Technology Process of N-(tri-(isopropyl)silyloxycarbonyl)-2-(4-benzyloxy-3-methoxyphenyl)-4,5-methylenedioxybenzylamine

There total 6 articles about N-(tri-(isopropyl)silyloxycarbonyl)-2-(4-benzyloxy-3-methoxyphenyl)-4,5-methylenedioxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 124-38-9,18923-20-1
carbon dioxide

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 438036-64-7
2-(4-benzyloxy-3-methoxyphenyl)-4,5-methylenedioxybenzylamine

: 438036-72-7
N-(tri-(isopropyl)silyloxycarbonyl)-2-(4-benzyloxy-3-methoxyphenyl)-4,5-methylenedioxybenzylamine

Guidance literature:: With triethylamine; In dichloromethane; at -78 - 20 ℃; for 0.583333h;
DOI:10.1021/jo020010d

Reference yield:

: 69048-76-6
6-iodo-1,3-benzodioxole-5-methanol

: 438036-72-7
N-(tri-(isopropyl)silyloxycarbonyl)-2-(4-benzyloxy-3-methoxyphenyl)-4,5-methylenedioxybenzylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / Et₃N / CH₂Cl₂ / 4 h / 0 - 20 °C

2: 21 percent / 10percent Pd(PPh₃)4 / toluene / 96 h / Heating

3: 73 percent / TBAF / tetrahydrofuran / 0 - 20 °C

4: 53 percent / PPh₃; ZnN₆*2Pyr; DEAD / tetrahydrofuran / 0 - 20 °C

5: 72 percent / PPh₃ / H₂O; tetrahydrofuran / 96 h / 20 °C

6: 72 percent / Et₃N / CH₂Cl₂ / 0.58 h / -78 - 20 °C

With ZnN₆*2Pyr; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jo020010d

Reference yield:

: 438036-61-4
5-(triethylsilyloxymethyl)-6-iodo-1,3-benzodioxole

: 438036-72-7
N-(tri-(isopropyl)silyloxycarbonyl)-2-(4-benzyloxy-3-methoxyphenyl)-4,5-methylenedioxybenzylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 21 percent / 10percent Pd(PPh₃)4 / toluene / 96 h / Heating

2: 73 percent / TBAF / tetrahydrofuran / 0 - 20 °C

3: 53 percent / PPh₃; ZnN₆*2Pyr; DEAD / tetrahydrofuran / 0 - 20 °C

4: 72 percent / PPh₃ / H₂O; tetrahydrofuran / 96 h / 20 °C

5: 72 percent / Et₃N / CH₂Cl₂ / 0.58 h / -78 - 20 °C

With ZnN₆*2Pyr; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jo020010d