4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

Base Information

Chemical Name:4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid
CAS No.:1266520-05-1
Molecular Formula:C₁₆H₇Cl₂F₂NO₂S
Molecular Weight:386.206
Hs Code.:

Synonyms:4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

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Chemical Property of 4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

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Technology Process of 4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

There total 2 articles about 4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1266519-94-1
ethyl 5-bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate

: 328956-61-2
3-fluoro-5-chlorophenylboronic acid

: 1266520-05-1
4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 80 ℃; Inert atmosphere;

Reference yield:

: 1266519-92-9
ethyl 4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate

: 1266520-05-1
4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; iron(III) chloride / dichloromethane / 18 h / Reflux

2: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

With iron(III) chloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; dichloromethane; water;

Reference yield: 60.0%

: 1187919-27-2
imidazolidin-4-one trifluoroacetate

: 1266520-05-1
4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

: 1266519-47-4
1-{[4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;