1-{[4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

Base Information

Chemical Name:1-{[4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one
CAS No.:1266519-47-4
Molecular Formula:C₁₉H₁₁Cl₂F₂N₃O₂S
Molecular Weight:454.284
Hs Code.:

Synonyms:1-{[4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

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Chemical Property of 1-{[4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

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Technology Process of 1-{[4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

There total 3 articles about 1-{[4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1187919-27-2
imidazolidin-4-one trifluoroacetate

: 1266520-05-1
4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

: 1266519-47-4
1-{[4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1266519-94-1
ethyl 5-bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate

: 1266519-47-4
1-{[4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 2923-66-2
3-chloro-4-fluoroacetophenone

: 1266519-47-4
1-{[4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: bromine / diethyl ether; 1,4-dioxane / 4 h / 0 °C

2: ethanol / 18 h / Reflux

3: N-Bromosuccinimide; iron(III) chloride / dichloromethane / 18 h / Reflux

4: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With iron(III) chloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water;