ALPHA-METHYL-DL-HISTIDINE DIHYDROCHLORIDE

Base Information

• Chemical Name: ALPHA-METHYL-DL-HISTIDINE DIHYDROCHLORIDE
• CAS No.: 32381-18-3
• Molecular Formula: C₇H₁₁N₃O₂*2ClH
• Molecular Weight: 242.105
• Mol file: 32381-18-3.mol

Synonyms:DL-Histidine,a-methyl-, dihydrochloride;Histidine, 2-methyl-, dihydrochloride, DL- (6CI); Histidine, a-methyl-, dihydrochloride, DL-(8CI); DL-a-Methylhistidine dihydrochloride;a-Methyl-DL-histidinedihydrochloride; a-Methylhistidinedihydrochloride

Chemical Property of ALPHA-METHYL-DL-HISTIDINE DIHYDROCHLORIDE

Chemical Property:

• PSA: 92.00000
• LogP: 2.05850
• Storage Temp.: Store at RT.

Purity/Quality:

99% ^*data from raw suppliers

DL-alpha-Methylhistidine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of ALPHA-METHYL-DL-HISTIDINE DIHYDROCHLORIDE

There total 3 articles about ALPHA-METHYL-DL-HISTIDINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl α-<(4-chlorophenylmethylene)amino>-1-<(4-methylphenyl)sulphonyl>-1H-imidazole-4-(-)-propanoate (126357-19-5) → α-methyl-DL-histidine dihydrochloride (20500-12-3,32381-18-3,53941-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Bu₄NBr, KOH / acetonitrile / 0.58 h / 5 °C

2: 1.) aq. HCl, 2.) aq. HCl / 1) reflux, 16 h

With hydrogenchloride; potassium hydroxide; tetrabutylammomium bromide; In acetonitrile;

Reference yield:

l-histidine methyl ester dihydrochloride (4467-54-3,5619-10-3,7389-87-9,18684-16-7,22888-60-4,32381-17-2,92742-29-5,100009-20-9) → α-methyl-DL-histidine dihydrochloride (20500-12-3,32381-18-3,53941-33-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) MgSO₄, Et₃N, 2.) Et₃N / 1) CH₂Cl₂, 2 h, room temperature; 2) 10 deg C, 1/2 h, CH₂Cl₂

2: Bu₄NBr, KOH / acetonitrile / 0.58 h / 5 °C

3: 1.) aq. HCl, 2.) aq. HCl / 1) reflux, 16 h

With hydrogenchloride; potassium hydroxide; tetrabutylammomium bromide; magnesium sulfate; triethylamine; In acetonitrile;

Reference yield:

methyl α-<(4-chlorophenylmethylene)amino>-α-methyl-1-<(4-methylphenyl)sulfonyl>-1H-imidazole-4-(+/-)-propanoate (126357-20-8) → α-methyl-DL-histidine dihydrochloride (20500-12-3,32381-18-3,53941-33-6)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1) reflux, 16 h;

upstream raw materials:

methyl α-<(4-chlorophenylmethylene)amino>-α-methyl-1-<(4-methylphenyl)sulfonyl>-1H-imidazole-4-(+/-)-propanoate

methyl α-<(4-chlorophenylmethylene)amino>-1-<(4-methylphenyl)sulphonyl>-1H-imidazole-4-(-)-propanoate

l-histidine methyl ester dihydrochloride