(S)-N-{1-[2-(4-amino-3-cyanophenylamino)-6-propylpyrimidin-4-yl]pyrrolidin-3-yl}acetamide hydrochloride

Base Information

• Chemical Name: (S)-N-{1-[2-(4-amino-3-cyanophenylamino)-6-propylpyrimidin-4-yl]pyrrolidin-3-yl}acetamide hydrochloride
• CAS No.: 1394316-97-2
• Molecular Formula: C₂₀H₂₅N₇O*ClH
• Molecular Weight: 415.926
• Mol file: 1394316-97-2.mol

Synonyms:(S)-N-{1-[2-(4-amino-3-cyanophenylamino)-6-propylpyrimidin-4-yl]pyrrolidin-3-yl}acetamide hydrochloride

Chemical Property of (S)-N-{1-[2-(4-amino-3-cyanophenylamino)-6-propylpyrimidin-4-yl]pyrrolidin-3-yl}acetamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-{1-[2-(4-amino-3-cyanophenylamino)-6-propylpyrimidin-4-yl]pyrrolidin-3-yl}acetamide hydrochloride

There total 3 articles about (S)-N-{1-[2-(4-amino-3-cyanophenylamino)-6-propylpyrimidin-4-yl]pyrrolidin-3-yl}acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-[1-(2-chloro-6-propylpyrimidin-4-yl)pyrrolidin-3-yl]acetamide (1394321-80-2) + 2-cyano-1,4-phenylenediamine (14346-13-5) → (S)-N-{1-[2-(4-amino-3-cyanophenylamino)-6-propylpyrimidin-4-yl]pyrrolidin-3-yl}acetamide hydrochloride (1394316-97-2)

Guidance literature:

In butan-1-ol; for 0.666667h; Microwave irradiation;

Reference yield:

5-nitroanthranilonitrile (17420-30-3) → (S)-N-{1-[2-(4-amino-3-cyanophenylamino)-6-propylpyrimidin-4-yl]pyrrolidin-3-yl}acetamide hydrochloride (1394316-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

2: butan-1-ol / 0.67 h / Microwave irradiation

With hydrogen; palladium 10% on activated carbon; In methanol; butan-1-ol;

Reference yield:

2,6-dichloro-4-n-propyl-pyrimidine (89938-07-8) → (S)-N-{1-[2-(4-amino-3-cyanophenylamino)-6-propylpyrimidin-4-yl]pyrrolidin-3-yl}acetamide hydrochloride (1394316-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / chloroform / 1 h / 60 °C

2: butan-1-ol / 0.67 h / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; In chloroform; butan-1-ol;

upstream raw materials:

2,6-dichloro-4-n-propyl-pyrimidine

5-nitroanthranilonitrile

(S)-N-[1-(2-chloro-6-propylpyrimidin-4-yl)pyrrolidin-3-yl]acetamide

2-cyano-1,4-phenylenediamine