5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-pyridin-2-ylmethyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

Base Information

Chemical Name:5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-pyridin-2-ylmethyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one
CAS No.:1441741-52-1
Molecular Formula:C₂₇H₂₃Cl₂FN₄O
Molecular Weight:509.41
Hs Code.:

Synonyms:5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-pyridin-2-ylmethyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

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Chemical Property of 5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-pyridin-2-ylmethyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

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Technology Process of 5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-pyridin-2-ylmethyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

There total 5 articles about 5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-pyridin-2-ylmethyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1441738-77-7
5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

: 31106-82-8
2-(bromomethyl)pyridine hydrobromide

: 1441741-52-1
5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-pyridin-2-ylmethyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

Guidance literature:: 5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.0833333h; Inert atmosphere;

2-(bromomethyl)pyridine hydrobromide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h;

Reference yield:

: 2106-04-9
3-chloro-2-fluoroaniline

: 1441741-52-1
5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-pyridin-2-ylmethyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 3 h / Reflux

2.1: acetic acid; hydrazine hydrate / ethanol / 1.5 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Inert atmosphere

3.2: 0.17 h / 20 °C

With sodium hydride; hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 5-methyl-2,4-dioxo-hexanoic acid ethyl ester sodium salt

: 1441741-52-1
5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-methyl-phenyl)-3-isopropyl-2-pyridin-2-ylmethyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 3 h / Reflux

2.1: acetic acid; hydrazine hydrate / ethanol / 1.5 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Inert atmosphere

3.2: 0.17 h / 20 °C

With sodium hydride; hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide; mineral oil;