(S)-2-Benzyloxycarbonylamino-3-{4-benzyloxy-3-[4-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-ylmethyl)-phenoxy]-phenyl}-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-3-{4-benzyloxy-3-[4-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-ylmethyl)-phenoxy]-phenyl}-propionic acid methyl ester
CAS No.:120363-17-9
Molecular Formula:C₄₁H₄₅N₃O₈
Molecular Weight:707.824
Hs Code.:

(S)-2-Benzyloxycarbonylamino-3-{4-benzyloxy-3-[4-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-ylmethyl)-phenoxy]-phenyl}-propionic acid methyl ester

Synonyms:(S)-2-Benzyloxycarbonylamino-3-{4-benzyloxy-3-[4-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-ylmethyl)-phenoxy]-phenyl}-propionic acid methyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-3-{4-benzyloxy-3-[4-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-ylmethyl)-phenoxy]-phenyl}-propionic acid methyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-3-{4-benzyloxy-3-[4-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-ylmethyl)-phenoxy]-phenyl}-propionic acid methyl ester

There total 18 articles about (S)-2-Benzyloxycarbonylamino-3-{4-benzyloxy-3-[4-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-ylmethyl)-phenoxy]-phenyl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1005-30-7
sodium 4-iodo-benzoate

: 120363-17-9
(S)-2-Benzyloxycarbonylamino-3-{4-benzyloxy-3-[4-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-ylmethyl)-phenoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / NaH, CuBr*S(CH₃)2 / nitrobenzene / 8 h / 130 °C

2: 89 percent / BH₃*THF / tetrahydrofuran / 3 h / 0 °C

3: 72 percent / CBr₄, (C₆H₅)3P / diethyl ether / 25 °C

4: 1.) NaH / 1.) THF, 0 deg C, 5 min, 2.) -78 deg C, 14 h

With borane-THF; copper(I) bromide dimethylsulfide complex; carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; nitrobenzene;
DOI:10.1021/jo00272a003

Reference yield:

: 120385-11-7
N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine methyl ester

: 120363-17-9
(S)-2-Benzyloxycarbonylamino-3-{4-benzyloxy-3-[4-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-ylmethyl)-phenoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / CBr₄, (C₆H₅)3P / diethyl ether / 25 °C

2: 1.) NaH / 1.) THF, 0 deg C, 5 min, 2.) -78 deg C, 14 h

With carbon tetrabromide; sodium hydride; triphenylphosphine; In diethyl ether;
DOI:10.1021/jo00272a003

Reference yield:

: 120363-13-5
tert-butyl 4-iodobenzoate

: 120363-17-9
(S)-2-Benzyloxycarbonylamino-3-{4-benzyloxy-3-[4-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-ylmethyl)-phenoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 46 percent / NaH, CuBr*S(CH₃)2 / nitrobenzene / 8 h / 130 °C

2: 95 percent / 3.0 M HCl / ethyl acetate / 1.5 h / 25 °C

3: 89 percent / BH₃*THF / tetrahydrofuran / 3 h / 0 °C

4: 72 percent / CBr₄, (C₆H₅)3P / diethyl ether / 25 °C

5: 1.) NaH / 1.) THF, 0 deg C, 5 min, 2.) -78 deg C, 14 h

With hydrogenchloride; borane-THF; copper(I) bromide dimethylsulfide complex; carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethyl acetate; nitrobenzene;
DOI:10.1021/jo00272a003