Technology Process of (2S,4R)-1-(benzyloxy)-5-<(tert-butyl)diphenylsilyloxy>-2,4-dimethylpentan-3-one
There total 8 articles about (2S,4R)-1-(benzyloxy)-5-<(tert-butyl)diphenylsilyloxy>-2,4-dimethylpentan-3-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) 55percent NaH, 2) Et4NI / 1) hexane, DMF, r.t., 1 h, 2) r.t., 16 h
2: 92 percent / conc. HCl / tetrahydrofuran / 6 h / Ambient temperature
3: 94 percent / imidazole, 4 Angstroem molecular sieves / dimethylformamide / 23 h / Ambient temperature
With
1H-imidazole; hydrogenchloride; 4 A molecular sieve; tetraethylammonium iodide; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19900730821
- Guidance literature:
-
Multi-step reaction with 7 steps
1: BH3*Me2S / a) THF, -10 deg C, 1.5 h, b) rt, 3h
2: Amberlyst 15 / methanol / 68 h
3: 96 percent / LiAlH4 / diethyl ether / a) -20 deg C, 3 h, b) r.t., 1.5 h
4: 1) 55percent NaH, 2) Et4NI / 1) hexane, DMF, r.t., 1 h, 2) r.t., 16 h
5: 92 percent / conc. HCl / tetrahydrofuran / 6 h / Ambient temperature
6: 94 percent / imidazole, 4 Angstroem molecular sieves / dimethylformamide / 23 h / Ambient temperature
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; Amberlyst 15; dimethylsulfide borane complex; 4 A molecular sieve; tetraethylammonium iodide; sodium hydride;
In
tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19900730821
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 96 percent / LiAlH4 / diethyl ether / a) -20 deg C, 3 h, b) r.t., 1.5 h
2: 1) 55percent NaH, 2) Et4NI / 1) hexane, DMF, r.t., 1 h, 2) r.t., 16 h
3: 92 percent / conc. HCl / tetrahydrofuran / 6 h / Ambient temperature
4: 94 percent / imidazole, 4 Angstroem molecular sieves / dimethylformamide / 23 h / Ambient temperature
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; 4 A molecular sieve; tetraethylammonium iodide; sodium hydride;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19900730821
