tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate

Base Information

Chemical Name:tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate
CAS No.:1237518-84-1
Molecular Formula:C₃₀H₃₄N₂O₅
Molecular Weight:502.61
Hs Code.:

Synonyms:tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate

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Chemical Property of tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate

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Technology Process of tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate

There total 10 articles about tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1237518-83-0
tert-butyl 2-(2-acetoxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate

: 1237518-84-1
tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate

Guidance literature:: tert-butyl 2-(2-acetoxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate; With water; sodium hydroxide; In 1,4-dioxane; at 50 - 55 ℃; for 2h;

With citric acid; In water; ethyl acetate;

Reference yield:

: 1237518-05-6
2-acetoxy-5-(piperidin-1-yl)benzoic acid

: 1237518-84-1
tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C / Cooling with ice

2: pyridine / dichloromethane / 1.5 h / 20 °C

3: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 - 55 °C

With pyridine; oxalyl dichloride; water; sodium hydroxide; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 5720-06-9
2-Methoxyphenylboronic acid

: 1237518-84-1
tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 2.5 h / Reflux; Inert atmosphere

2: sodium formate; acetic acid / palladium 10% on activated carbon / isopropyl alcohol; water / 2 h / Reflux

3: pyridine / dichloromethane / 1.5 h / 20 °C

4: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 - 55 °C

With pyridine; water; sodium formate; sodium carbonate; acetic acid; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; isopropyl alcohol;