(2S,4S,5R,6R)-4-Acetoxy-2-[(2R,3S,4S,5R,6R)-3-acetoxy-2-acetoxymethyl-5-benzoyloxy-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-5-acetylamino-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2S,4S,5R,6R)-4-Acetoxy-2-[(2R,3S,4S,5R,6R)-3-acetoxy-2-acetoxymethyl-5-benzoyloxy-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-5-acetylamino-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester
CAS No.:187233-03-0
Molecular Formula:C₄₂H₅₉NO₂₁Si
Molecular Weight:942.01
Hs Code.:

(2S,4S,5R,6R)-4-Acetoxy-2-[(2R,3S,4S,5R,6R)-3-acetoxy-2-acetoxymethyl-5-benzoyloxy-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-5-acetylamino-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

Synonyms:(2S,4S,5R,6R)-4-Acetoxy-2-[(2R,3S,4S,5R,6R)-3-acetoxy-2-acetoxymethyl-5-benzoyloxy-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-5-acetylamino-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

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Chemical Property of (2S,4S,5R,6R)-4-Acetoxy-2-[(2R,3S,4S,5R,6R)-3-acetoxy-2-acetoxymethyl-5-benzoyloxy-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-5-acetylamino-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

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Technology Process of (2S,4S,5R,6R)-4-Acetoxy-2-[(2R,3S,4S,5R,6R)-3-acetoxy-2-acetoxymethyl-5-benzoyloxy-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-5-acetylamino-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

There total 6 articles about (2S,4S,5R,6R)-4-Acetoxy-2-[(2R,3S,4S,5R,6R)-3-acetoxy-2-acetoxymethyl-5-benzoyloxy-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-5-acetylamino-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 108-24-7
acetic anhydride

: 187232-94-6
(2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-[(2R,3R,4S,5S,6R)-3-benzoyloxy-5-hydroxy-6-hydroxymethyl-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

: 187233-03-0
(2S,4S,5R,6R)-4-Acetoxy-2-[(2R,3S,4S,5R,6R)-3-acetoxy-2-acetoxymethyl-5-benzoyloxy-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-5-acetylamino-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: With pyridine; for 3h; Ambient temperature;
DOI:10.1016/S0968-0896(96)00165-4

Reference yield:

: 155155-64-9
(4S,5R,6R)-4-Acetoxy-5-acetylamino-2-phenylsulfanyl-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

: 187233-03-0
(2S,4S,5R,6R)-4-Acetoxy-2-[(2R,3S,4S,5R,6R)-3-acetoxy-2-acetoxymethyl-5-benzoyloxy-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-5-acetylamino-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / molecular sieves 3 A, N-iodosuccinimide, trifluoromethanesulfonic acid / acetonitrile / 3 h / -30 °C

2: 86 percent / pyridine, 4-dimethylaminopyridine / Ambient temperature

3: 94 percent / H₂, AcOH / 10percent Pd/C / 7 h / Ambient temperature

4: 91 percent / pyridine / 3 h / Ambient temperature

With pyridine; dmap; N-iodo-succinimide; trifluorormethanesulfonic acid; 3 A molecular sieve; hydrogen; acetic acid; palladium on activated charcoal; In acetonitrile;
DOI:10.1016/S0968-0896(96)00165-4

Reference yield:

: (2R,4aR,6R,7R,8R,8aR)-2-Phenyl-6-(2-trimethylsilanyl-ethoxy)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

: 187233-03-0
(2S,4S,5R,6R)-4-Acetoxy-2-[(2R,3S,4S,5R,6R)-3-acetoxy-2-acetoxymethyl-5-benzoyloxy-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-5-acetylamino-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / molecular sieves 3 A, N-iodosuccinimide, trifluoromethanesulfonic acid / acetonitrile / 3 h / -30 °C

2: 86 percent / pyridine, 4-dimethylaminopyridine / Ambient temperature

3: 94 percent / H₂, AcOH / 10percent Pd/C / 7 h / Ambient temperature

4: 91 percent / pyridine / 3 h / Ambient temperature

With pyridine; dmap; N-iodo-succinimide; trifluorormethanesulfonic acid; 3 A molecular sieve; hydrogen; acetic acid; palladium on activated charcoal; In acetonitrile;
DOI:10.1016/S0968-0896(96)00165-4