(Z)-5-(4-hydroxy-3-methoxybenzyl idene)-3-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

Base Information

Chemical Name:(Z)-5-(4-hydroxy-3-methoxybenzyl idene)-3-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one
CAS No.:1448459-17-3
Molecular Formula:C₂₅H₁₉FO₆S
Molecular Weight:466.487
Hs Code.:

Synonyms:(Z)-5-(4-hydroxy-3-methoxybenzyl idene)-3-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

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Chemical Property of (Z)-5-(4-hydroxy-3-methoxybenzyl idene)-3-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

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Technology Process of (Z)-5-(4-hydroxy-3-methoxybenzyl idene)-3-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

There total 5 articles about (Z)-5-(4-hydroxy-3-methoxybenzyl idene)-3-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 121-33-5,8014-42-4
vanillin

: 157672-00-9
3-(4-fluorophenyl)-4-<4-(methylsulfonyl)phenyl>-5H-furan-2-one

: 1448459-17-3
(Z)-5-(4-hydroxy-3-methoxybenzyl idene)-3-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

Guidance literature:: With sodium carbonate; In methanol; at 65 ℃; stereoselective reaction;
DOI:10.1016/j.ejmech.2013.04.062

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 1448459-17-3
(Z)-5-(4-hydroxy-3-methoxybenzyl idene)-3-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; dihydrogen peroxide; sulfuric acid / 2 h / 0 - 70 °C

2.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C

2.2: 2.5 h / 25 - 58 °C

3.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 1 h

3.3: 4 h / 60 °C

4.1: sodium carbonate / methanol / 65 °C

With sulfuric acid; hydrogen bromide; dihydrogen peroxide; sodium carbonate; acetic acid; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.04.062

Reference yield:

: 10297-73-1
4-(methanesulfonyl)acetophenone

: 1448459-17-3
(Z)-5-(4-hydroxy-3-methoxybenzyl idene)-3-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C

1.2: 2.5 h / 25 - 58 °C

2.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 1 h

2.3: 4 h / 60 °C

3.1: sodium carbonate / methanol / 65 °C

With hydrogen bromide; sodium carbonate; acetic acid; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.04.062