3-Pyridinol,6-chloro-2-methyl-(9CI)

Base Information

• Chemical Name: 3-Pyridinol,6-chloro-2-methyl-(9CI)
• CAS No.: 218770-02-6
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.573
• Hs Code.: 2933399090
• Mol file: 218770-02-6.mol

Synonyms:6-chloro-2-(methylsulfanyl)pyrimidine-4-carboxamide;;4-Pyrimidinecarboxamide,6-chloro-2-(methylthio);;6-chloro-2-methylsulfanyl-pyrimidine-4-carboxylic acid amide;;6-Chlor-2-methylmercapto-pyrimidin-4-carbonsaeureamid;;6-chloro-2-methyl-pyridin-3-ol;;6-Chlor-2-methyl-pyridin-3-ol;;

Chemical Property of 3-Pyridinol,6-chloro-2-methyl-(9CI)

Chemical Property:

• Melting Point: 208 oC
• Boiling Point: 332.8±37.0 °C(Predicted)
• PKA: 9.92±0.10(Predicted)
• PSA: 33.12000
• Density: 1.313
• LogP: 1.74900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloro-2-methylpyridin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinol,6-chloro-2-methyl-(9CI)

There total 5 articles about 3-Pyridinol,6-chloro-2-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetic acid 6-chloro-2-methyl-pyridin-3-yl ester → 6-chloro-2-methyl-pyridin-3-ol (218770-02-6)

Guidance literature:

acetic acid 6-chloro-2-methyl-pyridin-3-yl ester; With water; sodium hydroxide; at 0 - 20 ℃; for 1.25h;

With hydrogenchloride; water;

Reference yield:

→ 6-chloro-2-methyl-pyridin-3-ol (218770-02-6)

Guidance literature:

DOI:10.1021/ja01193a016

Reference yield:

3-amino-6-chloro-2-methylpyridine (164666-68-6) → 6-chloro-2-methyl-pyridin-3-ol (218770-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaNO₂, HBF₄ / 2.) reflux

2: NaOH

With sodium hydroxide; tetrafluoroboric acid; sodium nitrite;

DOI:10.1016/S0960-894X(98)00504-6

upstream raw materials:

3-amino-6-chloro-2-methylpyridine

6-chloro-4-methyl-3-nitropyridine