2-(6-hydroxymethylhepta-2,6-dienyl)-2-(3-phenylallyl)-malonic acid diethyl ester

Base Information

Chemical Name:2-(6-hydroxymethylhepta-2,6-dienyl)-2-(3-phenylallyl)-malonic acid diethyl ester
CAS No.:606133-09-9
Molecular Formula:C₂₄H₃₂O₅
Molecular Weight:400.515
Hs Code.:

Synonyms:2-(6-hydroxymethylhepta-2,6-dienyl)-2-(3-phenylallyl)-malonic acid diethyl ester

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Chemical Property of 2-(6-hydroxymethylhepta-2,6-dienyl)-2-(3-phenylallyl)-malonic acid diethyl ester

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Technology Process of 2-(6-hydroxymethylhepta-2,6-dienyl)-2-(3-phenylallyl)-malonic acid diethyl ester

There total 6 articles about 2-(6-hydroxymethylhepta-2,6-dienyl)-2-(3-phenylallyl)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(Z)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-hepta-2,6-dienyl]-2-((E)-3-phenyl-allyl)-malonic acid diethyl ester

: 606133-09-9
2-(6-hydroxymethylhepta-2,6-dienyl)-2-(3-phenylallyl)-malonic acid diethyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h;
DOI:10.1021/ja036263l

Reference yield:

: 63082-55-3
diethyl (E)-cinnamyl malonate

: 606133-09-9
2-(6-hydroxymethylhepta-2,6-dienyl)-2-(3-phenylallyl)-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: tetrahydrofuran / 1 h

2.1: 45 mg / TBAF / tetrahydrofuran / 1 h

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ja036263l

Reference yield:

: (Z)-2-Methylene-7-(tetrahydro-pyran-2-yloxy)-hept-5-en-1-ol

: 606133-09-9
2-(6-hydroxymethylhepta-2,6-dienyl)-2-(3-phenylallyl)-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 83 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 4 h / 0 - 20 °C

2.1: 91 percent / p-toluenesulfonic acid; methanol / 2 h / 20 °C

3.1: Et₃N / CH₂Cl₂ / 0.5 h

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: tetrahydrofuran / 1 h

5.1: 45 mg / TBAF / tetrahydrofuran / 1 h

With methanol; dmap; tetrabutyl ammonium fluoride; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja036263l