(1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-YL)methanol

Base Information

Chemical Name:(1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-YL)methanol
CAS No.:218631-47-1
Molecular Formula:C12H11 F3 N2 O2
Molecular Weight:272.227
Hs Code.:
DSSTox Substance ID:DTXSID70466992
Wikidata:Q82293719
Mol file:218631-47-1.mol

Synonyms:218631-47-1;(1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-5-YL)METHANOL;[2-(4-methoxyphenyl)-5-(trifluoromethyl)pyrazol-3-yl]methanol;SCHEMBL6176465;DTXSID70466992;AB44128;C90431;3-trifluoromethyl-5-hydroxymethyl-1 -(4-methoxyphenyl)-1H-pyrazole;3-trifluoromethyl-5-hydroxymethyl-1-(4-methoxyphenyl)-1H-pyrazole

Suppliers and Price of (1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-YL)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-5-YL)METHANOL 95.00%
5MG
$ 498.64

Total 3 raw suppliers

Chemical Property of (1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-YL)methanol

Chemical Property:

PSA：47.28000
LogP:2.39200
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:272.07726208
Heavy Atom Count:19
Complexity:293

Purity/Quality:

98%min ^*data from raw suppliers

(1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-5-YL)METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)N2C(=CC(=N2)C(F)(F)F)CO

Technology Process of (1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-YL)methanol

There total 5 articles about (1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-YL)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 218632-10-1
5-methyl-1-(4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole

: 218631-47-1
5-hydroxymethyl-1-(4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: N-bromosuccinimide; benzoyl peroxide / CCl₄ / 18 h / Heating; irradiation

2: 18-crown-6 / acetonitrile / 18 h / 20 °C

3: 16.43 g / IR₄₀₀(OH^-) resin / methanol / 3 h / 20 °C

With N-Bromosuccinimide; 18-crown-6 ether; IR₄₀₀(OH^-) resin; dibenzoyl peroxide; In methanol; tetrachloromethane; acetonitrile;
DOI:10.1021/jm030212h

Reference yield:

: 637318-19-5
acetic acid 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazol-3-ylmethyl ester

: 218631-47-1
5-hydroxymethyl-1-(4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole

Guidance literature:: With IR₄₀₀(OH^-) resin; In methanol; at 20 ℃; for 3h;
DOI:10.1021/jm030212h

Reference yield:

: 367-57-7
1,1,1-Trifluoro-2,4-pentanedione

: 218631-47-1
5-hydroxymethyl-1-(4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / AcOH / 2-methoxy-ethanol / 18 h / Heating

2: N-bromosuccinimide; benzoyl peroxide / CCl₄ / 18 h / Heating; irradiation

3: 18-crown-6 / acetonitrile / 18 h / 20 °C

4: 16.43 g / IR₄₀₀(OH^-) resin / methanol / 3 h / 20 °C

With N-Bromosuccinimide; 18-crown-6 ether; IR₄₀₀(OH^-) resin; acetic acid; dibenzoyl peroxide; In methanol; tetrachloromethane; 2-methoxy-ethanol; acetonitrile;
DOI:10.1021/jm030212h