4β-(4-azidophenyl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin

Base Information

• Chemical Name: 4β-(4-azidophenyl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin
• CAS No.: 692755-54-7
• Molecular Formula: C₃₃H₃₈N₄O₉SSi
• Molecular Weight: 694.838
• Mol file: 692755-54-7.mol

Synonyms:4β-(4-azidophenyl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin

Chemical Property of 4β-(4-azidophenyl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4β-(4-azidophenyl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin

There total 3 articles about 4β-(4-azidophenyl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4?azidobenezenesulfonyl chloride (15001-44-2) + 4-β-amino-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin (692755-45-6) → 4β-(4-azidophenyl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin (692755-54-7)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jm031117b

Reference yield:

(5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one (117507-84-3) → 4β-(4-azidophenyl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin (692755-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / imidazole / dimethylformamide / 17 h

2: 94 percent / DABCO / CH₂Cl₂ / 18 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm031117b

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 4β-(4-azidophenyl)sulfonamido-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin (692755-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / imidazole / dimethylformamide / 17 h

2: 94 percent / DABCO / CH₂Cl₂ / 18 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm031117b

upstream raw materials:

4?azidobenezenesulfonyl chloride

4-β-amino-4'-tert-butyldimethylsilyloxy-4'-O-demethyl-4-desoxypodophyllotoxin

(5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

tert-butyldimethylsilyl chloride

Downstream raw materials:

4-Azido-N-[(5S,5aS,8aR,9R)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-benzenesulfonamide