Carbamic acid, [(3S,4S)-4-(fluoromethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl

Base Information

Chemical Name:Carbamic acid, [(3S,4S)-4-(fluoromethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl
CAS No.:218281-40-4
Molecular Formula:C10H19 F N2 O2
Molecular Weight:218.271
Hs Code.:
Mol file:218281-40-4.mol

Synonyms:Carbamicacid, [(3S,4S)-4-(fluoromethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester(9CI); (3S,4S)-3-(tert-Butoxycarbonylamino)-4-(fluoromethyl)pyrrolidine;tert-Butyl [(3S,4S)-4-(fluoromethyl)pyrrolidin-3-yl]carbamate

Suppliers and Price of Carbamic acid, [(3S,4S)-4-(fluoromethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Carbamic acid, [(3S,4S)-4-(fluoromethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl

Chemical Property:

Boiling Point:315.2±27.0 °C(Predicted)
PKA:11.96±0.40(Predicted)
PSA：50.36000
Density:1.08±0.1 g/cm3(Predicted)
LogP:1.78830

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(3S,4S)-4-(fluoromethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl

There total 8 articles about Carbamic acid, [(3S,4S)-4-(fluoromethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 218281-37-9
3(S)-tert-butoxycarbonylamino-4(S)-fluoromethyl-1-[N-1(R)-phenylethyl]pyrrolidine

: 218281-40-4,1033718-06-7,213388-73-9,213388-74-0
3(S)-tert-butoxycarbonylamino-4(S)-fluoromethylpyrrolidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; water; at 50 ℃; for 15h; under 760 Torr;
DOI:10.1248/cpb.48.1667

Reference yield:

: 190957-22-3
(4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one

: 218281-40-4,1033718-06-7,213388-73-9,213388-74-0
3(S)-tert-butoxycarbonylamino-4(S)-fluoromethylpyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: Et₃N / CHCl₃ / 0.5 h / 0 °C

2.1: tetra-n-butylammonium fluoride / tetrahydrofuran / 1.5 h / Heating

3.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

3.2: 73 percent / O₂ / tetrahydrofuran / 0.5 h / -78 °C

4.1: Et₃N / CH₂Cl₂ / 0.5 h / -10 °C

5.1: NaN₃ / dimethylformamide / 16 h / 100 °C

6.1: 72 percent / H₂ / 10 percent Pd/C / H₂O; methanol / 15 h / 20 °C / 760 Torr

7.1: BH₃*THF / tetrahydrofuran / 18 h / 20 °C

7.2: 96 percent / Et₃N / aq. ethanol / 2 h / Heating

8.1: H₂ / 10 percent Pd/C / ethanol; H₂O / 15 h / 50 °C / 760 Torr

With sodium azide; borane-THF; tetrabutyl ammonium fluoride; hydrogen; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.48.1667

Reference yield:

: 252051-14-2
(4R,1'R)-1-(1'-phenylethyl)-4-methanesulfonyloxymethylpyrrolidin-2-one

: 218281-40-4,1033718-06-7,213388-73-9,213388-74-0
3(S)-tert-butoxycarbonylamino-4(S)-fluoromethylpyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetra-n-butylammonium fluoride / tetrahydrofuran / 1.5 h / Heating

2.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

2.2: 73 percent / O₂ / tetrahydrofuran / 0.5 h / -78 °C

3.1: Et₃N / CH₂Cl₂ / 0.5 h / -10 °C

4.1: NaN₃ / dimethylformamide / 16 h / 100 °C

5.1: 72 percent / H₂ / 10 percent Pd/C / H₂O; methanol / 15 h / 20 °C / 760 Torr

6.1: BH₃*THF / tetrahydrofuran / 18 h / 20 °C

6.2: 96 percent / Et₃N / aq. ethanol / 2 h / Heating

7.1: H₂ / 10 percent Pd/C / ethanol; H₂O / 15 h / 50 °C / 760 Torr

With sodium azide; borane-THF; tetrabutyl ammonium fluoride; hydrogen; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.48.1667