252051-14-2

Basic information

• Product Name: (4R,1'R)-1-(1'-phenylethyl)-4-methanesulfonyloxymethylpyrrolidin-2-one
• Synonyms: (4R,1'R)-1-(1'-phenylethyl)-4-methanesulfonyloxymethylpyrrolidin-2-one
• CAS NO: 252051-14-2
• Molecular Weight: 297.375
• Mol File: 252051-14-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4R,1'R)-1-(1'-phenylethyl)-4-methanesulfonyloxymethylpyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,1'R)-1-(1'-phenylethyl)-4-methanesulfonyloxymethylpyrrolidin-2-one(252051-14-2)
• EPA Substance Registry System: (4R,1'R)-1-(1'-phenylethyl)-4-methanesulfonyloxymethylpyrrolidin-2-one(252051-14-2)

Safety Data

• Hazardous Substances Data: 252051-14-2(Hazardous Substances Data)

Upstream product

• 252051-12-0 (4R,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde 
• 124-63-0 methanesulfonyl chloride 
• 190957-22-3 (4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one 

Downstream Products

• 252051-16-4 (3S,1'S)-1-(1'-phenylethyl)-3-naphthylaminomethylpyrrolidine 
• 218281-25-5 7-[3(S)-amino-4(S)-fluoromethyl-1-pyrrolidinyl]-6-fluoro-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid 
• 218281-35-7 3(S)-tert-butoxycarbonylamino-4(S)-fluoromethyl-1-[N-1(R)-phenylethyl]-2-pyrrolidone 
• 218281-37-9 3(S)-tert-butoxycarbonylamino-4(S)-fluoromethyl-1-[N-1(R)-phenylethyl]pyrrolidine 
• 1027014-09-0 Methanesulfonic acid (3R,4S)-4-fluoromethyl-2-oxo-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-yl ester 
• 218281-33-5 3(S)-azide-4(S)-fluoromethyl-1-[N-1(R)-phenylethyl]-2-pyrrolidone 
• 218281-40-4 3(S)-tert-butoxycarbonylamino-4(S)-fluoromethylpyrrolidine 
• 218281-31-3 4(S)-fluoromethyl-3(R)-hydroxy-1-[N-1(R)-phenylethyl]-2-pyrrolidone 
• 252051-15-3 (4S,1'R)-1-(1'-phenylethyl)-4-naphthylaminomethylpyrrolidin-2-one 

Relevant articles and documents

Ester derivatives

This invention relates to compounds which exhibit selective muscarinic M3 receptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I); 1[in which A signifies a group expressed by a formula (a0) or (b0); 2Ar signifies optionally substituted aryl or heteroaryl; B1 and B2 signify aliphatic hydrocarbon; R1 signifies fluorine-substituted cycloalkyl; R2, R3 and R4 signify lower alkyl, single bond or alkylene bonded to B1, or R2 and R3 are united to signify alkylene; R5 and R7 signify hydrogen, lower alkyl, or a single bond or alkylene bonded to B2; R6 signifies hydrogen, lower alkyl or a group expressed as —N(R8)R9; and X?signifies an anion].

New chiral 3-naphthylaminomethylpyrrolidines: An unexpected epimerisation reaction

New enantiomerically pure 3-naphthylaminomethylpyrrolidines (8), (9), (14) and (15) were obtained through simple steps starting from chiral 4- ethenylpyrrolidin-2-ones (2) and (3). On the other hand, starting from pyrrolidine (16), an epimerisation reacti