N-(4-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Base Information

Chemical Name:N-(4-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide
CAS No.:1254782-97-2
Molecular Formula:C₂₅H₂₇ClN₆O₃
Molecular Weight:494.981
Hs Code.:

Synonyms:N-(4-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

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Chemical Property of N-(4-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

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Technology Process of N-(4-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

There total 9 articles about N-(4-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 4-(4-aminophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl) pyrimidin-2-amine

: 814-68-6,25189-84-8
acryloyl chloride

: 1254782-97-2
N-(4-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/j.bmcl.2017.09.048

Reference yield:

: 1254783-90-8
2,5-dichloro-4-(4-nitrophenoxy)pyrimidine

: 1254782-97-2
N-(4-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / iso-butanol / 4 h / 100 °C

2: iron; ammonium chloride / tetrahydrofuran; water / 4 h / 65 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; iso-butanol;
DOI:10.1016/j.bmcl.2017.09.048

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1254782-97-2
N-(4-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol

3: trifluoroacetic acid / iso-butanol / 4 h / 100 °C

4: iron; ammonium chloride / tetrahydrofuran; water / 4 h / 65 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C

With palladium 10% on activated carbon; hydrogen; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; iso-butanol;
DOI:10.1016/j.bmcl.2017.09.048