N-{5-[4-(4-fluorobenzyl)-2R,5S-dimethyl-piperazine-1-carbonyl]-6-methoxy-3-trimethylsilanylethynyl-pyridin-2-yl}-acetamide

Base Information

Chemical Name:N-{5-[4-(4-fluorobenzyl)-2R,5S-dimethyl-piperazine-1-carbonyl]-6-methoxy-3-trimethylsilanylethynyl-pyridin-2-yl}-acetamide
CAS No.:680208-38-2
Molecular Formula:C₂₇H₃₅FN₄O₃Si
Molecular Weight:510.684
Hs Code.:

Synonyms:N-{5-[4-(4-fluorobenzyl)-2R,5S-dimethyl-piperazine-1-carbonyl]-6-methoxy-3-trimethylsilanylethynyl-pyridin-2-yl}-acetamide

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Chemical Property of N-{5-[4-(4-fluorobenzyl)-2R,5S-dimethyl-piperazine-1-carbonyl]-6-methoxy-3-trimethylsilanylethynyl-pyridin-2-yl}-acetamide

Chemical Property:

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Technology Process of N-{5-[4-(4-fluorobenzyl)-2R,5S-dimethyl-piperazine-1-carbonyl]-6-methoxy-3-trimethylsilanylethynyl-pyridin-2-yl}-acetamide

There total 12 articles about N-{5-[4-(4-fluorobenzyl)-2R,5S-dimethyl-piperazine-1-carbonyl]-6-methoxy-3-trimethylsilanylethynyl-pyridin-2-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 680208-36-0
N-{5-[4-(4-fluorobenzyl)-2R,5S-dimethyl-piperazine-1-carbonyl]-3-iodo-6-methoxy-pyridin-2-yl}-acetamide

: 1066-54-2
trimethylsilylacetylene

: 680208-38-2
N-{5-[4-(4-fluorobenzyl)-2R,5S-dimethyl-piperazine-1-carbonyl]-6-methoxy-3-trimethylsilanylethynyl-pyridin-2-yl}-acetamide

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 364066-92-2
(2S,5R)-1-(4-fluorobenzyl)-2,5-dimethylpiperazine

: 680208-38-2
N-{5-[4-(4-fluorobenzyl)-2R,5S-dimethyl-piperazine-1-carbonyl]-6-methoxy-3-trimethylsilanylethynyl-pyridin-2-yl}-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 20 °C

2: ammonia / methanol / 60 °C

3: potassium tert-butylate / Heating / reflux

4: N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate / dichloromethane / 20 °C

5: pyridine / dichloromethane / 20 °C

6: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0 - 20 °C

With pyridine; copper(l) iodide; potassium tert-butylate; ammonia; N,N,N-trimethylbenzenemethanaminium dichloroiodate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; calcium carbonate; bis-triphenylphosphine-palladium(II) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: (+/-)-N-4-fluorobenzyl-trans-2,5-dimethylpiperazine

: 680208-38-2
N-{5-[4-(4-fluorobenzyl)-2R,5S-dimethyl-piperazine-1-carbonyl]-6-methoxy-3-trimethylsilanylethynyl-pyridin-2-yl}-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: methanol / 2.5 h / 50 °C

2: sodium hydroxide / dichloromethane; water / 1.17 h / 20 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 20 °C

4: ammonia / methanol / 60 °C

5: potassium tert-butylate / Heating / reflux

6: N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate / dichloromethane / 20 °C

7: pyridine / dichloromethane / 20 °C

8: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0 - 20 °C

With pyridine; sodium hydroxide; copper(l) iodide; potassium tert-butylate; ammonia; N,N,N-trimethylbenzenemethanaminium dichloroiodate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; calcium carbonate; bis-triphenylphosphine-palladium(II) chloride; In methanol; dichloromethane; water; N,N-dimethyl-formamide;