113082-27-2

Basic information

• Product Name: 2-chloro-6-fluoroquinazoline
• Synonyms: 2-chloro-6-fluoroquinazoline
• CAS NO: 113082-27-2
• Molecular Formula: C8H4ClFN2
• Molecular Weight: 182.58
• Product Categories: CHIRAL CHEMICALS
• Mol File: 113082-27-2.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 183.981 °C at 760 mmHg
• Flash Point: 65.07 °C
• Appearance: /
• Density: 1.447 g/cm³
• Vapor Pressure: 1.03mmHg at 25°C
• Refractive Index: 1.634
• PKA: -0.44±0.30(Predicted)
• CAS DataBase Reference: 2-chloro-6-fluoroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-fluoroquinazoline(113082-27-2)
• EPA Substance Registry System: 2-chloro-6-fluoroquinazoline(113082-27-2)

Safety Data

• Hazardous Substances Data: 113082-27-2(Hazardous Substances Data)

Usage

General Description

2-chloro-6-fluoroquinazoline is a chemical compound with the formula C9H5ClFN2. It is a quinazoline derivative bearing a chlorine atom at the 2-position and a fluorine atom at the 6-position. 2-chloro-6-fluoroquinazoline is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its structure and properties make it a useful intermediate in organic chemistry, particularly in the development of new drugs and pesticides. Additionally, its ability to form various derivatives and analogs makes it a valuable tool for medicinal and chemical research.

InChI:InChI=1/C8H4ClFN2/c9-8-11-4-5-3-6(10)1-2-7(5)12-8/h1-4H

Upstream product

• 146829-56-3 2-amino-5-fluoro benzaldehyde 
• 61272-77-3 2-cyano-4-fluoroaniline 
• 88145-90-8 6-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 134517-57-0 2,4-dichloro-6-fluoro-quinazoline 
• 1085458-48-5 C₈H₅FN₂O 
• 391-93-5 ethyl 2-amino-5-fluorobenzoate 
• 603306-58-7 2-(dibutoxymethyl)-4-fluoro-1-nitrobenzene 
• 395-81-3 5-fluoro-2-nitrobenzaldehyde 
• 1085458-48-5 2-hydroxy-6-fluoroquinazoline 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 159418-71-0 [di-3,5-bis(trifluoromethyl)phenyl](diethyl-amino)phosphine 

Downstream Products

• 1030377-30-0 6-fluoro-2-{(5R)-5-methyl-4-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}quinazoline 
• 1085458-32-7 3-(6-fluoroquinazolin-2-yl)-10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane 
• 16499-45-9 7-fluoroquinazoline 
• 1624604-15-4 (4S,6S)-4-(2-fluoro-5-(6-fluoroquinazolin-2-yl)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 
• 1241052-35-6 C₂₅H₂₄FN₇O 
• 1241052-40-3 C₂₂H₂₃FN₄O 
• 1241052-37-8 C₂₅H₂₄FN₇O 
• 1241052-36-7 C₂₅H₂₄FN₇O 
• 1149352-60-2 6-fluoro-2-{(7S)-7-methyl-8-[2-(2H-1.2.3-triazol-2-yl)benzoyl]-5.8-diazaspiro[2.6]non-5-yl}quinazoline 
• 1149352-51-1 2-{6,7-dimethyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}-6-fluoroquinazoline 
• 1001857-52-8 6-fluoro-2-[(1S,5S)-6-(4-methoxyphenyl)-2,6-diazabicyclo[3.2.2]non-2-yl]quinazoline 
• 1001857-45-9 6-fluoro-2-[(1S,5S)-6-(4-methoxyphenyl)-3,6-diazabicyclo[3.2.2]non-3-yl]quinazoline 

Relevant articles and documents

INHIBITORS OF CYCLIN-DEPENDENT KINASES

Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF

The invention relates to octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof. Compounds and pharmaceutical compositions comprising the compounds provided herein are used for antagonizing orexin receptors. The invention also relates to processes for preparing the compounds and pharmaceutical compositions, and uses thereof in treating or preventing a disease related to orexin receptors.

Enantioselective synthesis of diaryl aziridines using tetrahydrothiophene- based chiral sulfides as organocatalysts

This work describes catalytic and asymmetric aziridinations (15 examples, 95-98% ee) of benzyl bromide and imines via the imino Corey-Chaykovsky reaction using (thiolan-2-yl)diarylmethanol benzyl ether as an organocatalyst. The catalyst and analogues thereof were prepared through an expeditious and efficient synthetic route featuring a double nucleophilic substitution and Shi epoxidation as key steps.