N-{1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethyl}acetamide

Base Information

• Chemical Name: N-{1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethyl}acetamide
• CAS No.: 1196968-74-7
• Molecular Formula: C₂₅H₂₇NO₃
• Molecular Weight: 389.494
• Mol file: 1196968-74-7.mol

Synonyms:N-{1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethyl}acetamide

Chemical Property of N-{1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethyl}acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethyl}acetamide

There total 5 articles about N-{1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

C23H25NO2 + acetic anhydride (108-24-7) → N-{1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethyl}acetamide (1196968-74-7)

Guidance literature:

With pyridine; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2021.116056

Reference yield:

1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethan-1-one + acetic acid (64-19-7,77671-22-8) → N-{1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethyl}acetamide (1196968-74-7)

Guidance literature:

1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethan-1-one; With ammonia; titanium(IV)isopropoxide; In ethanol; at 50 ℃; for 6h;

With sodium tetrahydroborate; at 20 ℃; for 2h;

acetic acid; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2009.08.077

Reference yield:

1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethan-1-one → N-{1-[4′-(4-propoxyphenoxy)[1,1′-biphenyl]-4-yl]ethyl}acetamide (1196968-74-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol / tetrahydrofuran / 1 h / 0 °C

2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 2 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C / 760.05 Torr

4: pyridine / 0.5 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmc.2021.116056

upstream raw materials:

acetic acid

acetic anhydride