1-{1-[2-(7-chloroquinolin-4-ylamino)ethyl]-1H-[1,2,3]triazol-4-yl}cyclohexanol

Base Information

Chemical Name:1-{1-[2-(7-chloroquinolin-4-ylamino)ethyl]-1H-[1,2,3]triazol-4-yl}cyclohexanol
CAS No.:1335447-19-2
Molecular Formula:C₁₉H₂₂ClN₅O
Molecular Weight:371.87
Hs Code.:

Synonyms:1-{1-[2-(7-chloroquinolin-4-ylamino)ethyl]-1H-[1,2,3]triazol-4-yl}cyclohexanol

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Chemical Property of 1-{1-[2-(7-chloroquinolin-4-ylamino)ethyl]-1H-[1,2,3]triazol-4-yl}cyclohexanol

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Technology Process of 1-{1-[2-(7-chloroquinolin-4-ylamino)ethyl]-1H-[1,2,3]triazol-4-yl}cyclohexanol

There total 4 articles about 1-{1-[2-(7-chloroquinolin-4-ylamino)ethyl]-1H-[1,2,3]triazol-4-yl}cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1145669-30-2
(2-azidoethyl)-(7-chloro-quinolin-4-yl)amine

: 78-27-3
1-Ethynylcyclohexan-1-ol

: 1335447-19-2
1-{1-[2-(7-chloroquinolin-4-ylamino)ethyl]-1H-[1,2,3]triazol-4-yl}cyclohexanol

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 40 ℃; for 3h;
DOI:10.1111/j.1747-0285.2011.01115.x

Reference yield:

: 852402-04-1
methanesulfonic acid 2-(7-chloro-quinolin-4-ylamino)ethyl ester

: 1335447-19-2
1-{1-[2-(7-chloroquinolin-4-ylamino)ethyl]-1H-[1,2,3]triazol-4-yl}cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 50 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 3 h / 40 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1111/j.1747-0285.2011.01115.x

Reference yield:

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 1335447-19-2
1-{1-[2-(7-chloroquinolin-4-ylamino)ethyl]-1H-[1,2,3]triazol-4-yl}cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1: 130 - 150 °C / Inert atmosphere; Neat (no solvent)

2: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 50 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 3 h / 40 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1111/j.1747-0285.2011.01115.x