(3-{[2-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-ethyl]-benzyl-amino}-propyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (3-{[2-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-ethyl]-benzyl-amino}-propyl)-carbamic acid tert-butyl ester
• CAS No.: 154920-49-7
• Molecular Formula: C₃₅H₅₁N₅O₂
• Molecular Weight: 573.822

Synonyms:(3-{[2-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-ethyl]-benzyl-amino}-propyl)-carbamic acid tert-butyl ester

Chemical Property of (3-{[2-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-ethyl]-benzyl-amino}-propyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (3-{[2-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-ethyl]-benzyl-amino}-propyl)-carbamic acid tert-butyl ester

There total 13 articles about (3-{[2-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-ethyl]-benzyl-amino}-propyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

16-cyano-9,12,15-tri(phenylmethyl)-2,2-dimethyl-3-oxa-4-oxo-5,9,12,15-tetraazahexadecane (154920-44-2) → (3-{[2-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-ethyl]-benzyl-amino}-propyl)-carbamic acid tert-butyl ester (154920-49-7)

Guidance literature:

With sodium hydroxide; hydrogen; nickel; In ethanol; for 12h; under 2327.2 Torr;

DOI:10.1002/jhet.5570300532

Reference yield:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) → (3-{[2-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-ethyl]-benzyl-amino}-propyl)-carbamic acid tert-butyl ester (154920-49-7)

Guidance literature:

Multi-step reaction with 11 steps

1: 81 percent / tetrahydrofuran / 6 h / Ambient temperature

2: 87 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

3: 92 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

4: magnesium sulfate / methanol / 4 h / Ambient temperature

5: NaBH₄ / methanol / Ambient temperature

6: 96 percent / KF/celite / acetonitrile / 12 h / 85 °C

7: 87 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

8: magnesium sulfate / methanol / 4 h / Ambient temperature

9: NaBH₄ / methanol / Ambient temperature

10: 85 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

11: 79 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

With potassium fluoride; sodium hydroxide; sodium tetrahydroborate; Celite; hydrogen; magnesium sulfate; nickel; In tetrahydrofuran; methanol; ethanol; acetonitrile;

DOI:10.1002/jhet.5570300532

Reference yield:

N-[N-(tert-Butyloxycarbonyl)-3-aminopropyl]benzylamine (90914-08-2) → (3-{[2-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-ethyl]-benzyl-amino}-propyl)-carbamic acid tert-butyl ester (154920-49-7)

Guidance literature:

Multi-step reaction with 10 steps

1: 87 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

2: 92 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

3: magnesium sulfate / methanol / 4 h / Ambient temperature

4: NaBH₄ / methanol / Ambient temperature

5: 96 percent / KF/celite / acetonitrile / 12 h / 85 °C

6: 87 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

7: magnesium sulfate / methanol / 4 h / Ambient temperature

8: NaBH₄ / methanol / Ambient temperature

9: 85 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

10: 79 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

With potassium fluoride; sodium hydroxide; sodium tetrahydroborate; Celite; hydrogen; magnesium sulfate; nickel; In methanol; ethanol; acetonitrile;

DOI:10.1002/jhet.5570300532

upstream raw materials:

16-cyano-9,12,15-tri(phenylmethyl)-2,2-dimethyl-3-oxa-4-oxo-5,9,12,15-tetraazahexadecane

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

N-[N-(tert-Butyloxycarbonyl)-3-aminopropyl]benzylamine

benzaldehyde

Downstream raw materials:

13-amino-1,4,7,10-tetra(phenylmethyl)-1,4,7,10-tetraazatridecane

9,12,15,18-tetra(phenylmethyl)-2,2-dimethyl-3-oxa-4-oxo-5,9,12,15,18-pentaazaoctadecane

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-<4,7,10,13-tetrakis(phenylmethyl)-4,7,10,13-tetraazatridec-1-yl>-2'-deoxyguanosine

C₆₃H₉₁N₉O₆Si₂

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