13-amino-1,4,7,10-tetra(phenylmethyl)-1,4,7,10-tetraazatridecane

Base Information

• Chemical Name: 13-amino-1,4,7,10-tetra(phenylmethyl)-1,4,7,10-tetraazatridecane
• CAS No.: 154920-37-3
• Molecular Formula: C₃₇H₄₉N₅
• Molecular Weight: 563.83
• Mol file: 154920-37-3.mol

Synonyms:

Chemical Property of 13-amino-1,4,7,10-tetra(phenylmethyl)-1,4,7,10-tetraazatridecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 13-amino-1,4,7,10-tetra(phenylmethyl)-1,4,7,10-tetraazatridecane

There total 16 articles about 13-amino-1,4,7,10-tetra(phenylmethyl)-1,4,7,10-tetraazatridecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[N-(tert-Butyloxycarbonyl)-3-aminopropyl]benzylamine (90914-08-2) → 13-amino-1,4,7,10-tetra(phenylmethyl)-1,4,7,10-tetraazatridecane (154920-37-3)

Guidance literature:

Multi-step reaction with 13 steps

1: 87 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

2: 92 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

3: magnesium sulfate / methanol / 4 h / Ambient temperature

4: NaBH₄ / methanol / Ambient temperature

5: 96 percent / KF/celite / acetonitrile / 12 h / 85 °C

6: 87 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

7: magnesium sulfate / methanol / 4 h / Ambient temperature

8: NaBH₄ / methanol / Ambient temperature

9: 85 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

10: 79 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

11: magnesium sulfate / methanol / 4 h / Ambient temperature

12: NaBH₄ / methanol / Ambient temperature

13: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

With potassium fluoride; sodium hydroxide; sodium tetrahydroborate; Celite; hydrogen; magnesium sulfate; trifluoroacetic acid; nickel; In methanol; ethanol; dichloromethane; acetonitrile;

DOI:10.1002/jhet.5570300532

Reference yield:

benzaldehyde (100-52-7) → 13-amino-1,4,7,10-tetra(phenylmethyl)-1,4,7,10-tetraazatridecane (154920-37-3)

Guidance literature:

Multi-step reaction with 11 steps

1: magnesium sulfate / methanol / 4 h / Ambient temperature

2: NaBH₄ / methanol / Ambient temperature

3: 96 percent / KF/celite / acetonitrile / 12 h / 85 °C

4: 87 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

5: magnesium sulfate / methanol / 4 h / Ambient temperature

6: NaBH₄ / methanol / Ambient temperature

7: 85 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

8: 79 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

9: magnesium sulfate / methanol / 4 h / Ambient temperature

10: NaBH₄ / methanol / Ambient temperature

11: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

With potassium fluoride; sodium hydroxide; sodium tetrahydroborate; Celite; hydrogen; magnesium sulfate; trifluoroacetic acid; nickel; In methanol; ethanol; dichloromethane; acetonitrile;

DOI:10.1002/jhet.5570300532

Reference yield:

N-benzyl-1,3-diaminopropane (13910-48-0) → 13-amino-1,4,7,10-tetra(phenylmethyl)-1,4,7,10-tetraazatridecane (154920-37-3)

Guidance literature:

Multi-step reaction with 14 steps

1: 81 percent / tetrahydrofuran / 6 h / Ambient temperature

2: 87 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

3: 92 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

4: magnesium sulfate / methanol / 4 h / Ambient temperature

5: NaBH₄ / methanol / Ambient temperature

6: 96 percent / KF/celite / acetonitrile / 12 h / 85 °C

7: 87 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

8: magnesium sulfate / methanol / 4 h / Ambient temperature

9: NaBH₄ / methanol / Ambient temperature

10: 85 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

11: 79 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

12: magnesium sulfate / methanol / 4 h / Ambient temperature

13: NaBH₄ / methanol / Ambient temperature

14: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

With potassium fluoride; sodium hydroxide; sodium tetrahydroborate; Celite; hydrogen; magnesium sulfate; trifluoroacetic acid; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;

DOI:10.1002/jhet.5570300532

upstream raw materials:

9,12,15,18-tetra(phenylmethyl)-2,2-dimethyl-3-oxa-4-oxo-5,9,12,15,18-pentaazaoctadecane

N-[N-(tert-Butyloxycarbonyl)-3-aminopropyl]benzylamine

benzaldehyde

N-benzyl-1,3-diaminopropane

Downstream raw materials:

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-6-O-(phenylmethyl)-N-<15-methyl-14-oxo-4,7,10,13-tetrakis(phenylmethyl)-4,7,10,13-tetraazahexadec-1-yl>-2'-deoxyguanosine

C₆₃H₉₁N₉O₆Si₂

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-<4,7,10,13-tetrakis(phenylmethyl)-4,7,10,13-tetraazatridec-1-yl>-2'-deoxyguanosine