6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'-chloro-4'',6''-O-cyclohexylidene-3',4'-dideoxy-4'-epi-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A

Base Information

Chemical Name:6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'-chloro-4'',6''-O-cyclohexylidene-3',4'-dideoxy-4'-epi-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A
CAS No.:134160-35-3
Molecular Formula:C₆₀H₇₄ClFN₄O₂₁S₄
Molecular Weight:1369.98
Hs Code.:

Synonyms:6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'-chloro-4'',6''-O-cyclohexylidene-3',4'-dideoxy-4'-epi-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'-chloro-4'',6''-O-cyclohexylidene-3',4'-dideoxy-4'-epi-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A

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Technology Process of 6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'-chloro-4'',6''-O-cyclohexylidene-3',4'-dideoxy-4'-epi-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A

There total 1 articles about 6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'-chloro-4'',6''-O-cyclohexylidene-3',4'-dideoxy-4'-epi-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 134160-33-1
6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'',6''-O-cyclohexylidene-3'-deoxy-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A

: 134160-35-3
6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'-chloro-4'',6''-O-cyclohexylidene-3',4'-dideoxy-4'-epi-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A

Guidance literature:: With pyridine; thionyl chloride; In dichloromethane; 1) dry ice-acetone cooling, 2) up to r. t., 5 h;
DOI:10.1016/0008-6215(91)80124-6

Reference yield: 75.0%

: 134160-35-3
6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'-chloro-4'',6''-O-cyclohexylidene-3',4'-dideoxy-4'-epi-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A

: 134160-36-4
4'-chloro-4'',6''-O-cyclohexylidene-3',4'-dideoxy-4'-epi-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; Ambient temperature;
DOI:10.1016/0008-6215(91)80124-6

Reference yield:

: 134160-35-3
6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'-chloro-4'',6''-O-cyclohexylidene-3',4'-dideoxy-4'-epi-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A

: 76582-92-8
6-O-amino-(3-amino-3-deoxy-α-D-glucopyranosyl)-2-deoxystreptamine monocarbonate

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 1 M aq. NaOH / dioxane / Ambient temperature

2: 1) liquid NH₃, Na, 2) 80percent aq. AcOH / 1) -50 deg C, 5 min, 2) 80 deg C, 30 min

With sodium hydroxide; ammonia; sodium; acetic acid; In 1,4-dioxane;
DOI:10.1016/0008-6215(91)80124-6