3',4'-dideoxy-3'-fluorokanamycin A monocarbonate

Base Information

Chemical Name:3',4'-dideoxy-3'-fluorokanamycin A monocarbonate
CAS No.:134160-39-7
Molecular Formula:CH₂O₃*C₁₈H₃₅FN₄O₉
Molecular Weight:532.521
Hs Code.:

Synonyms:

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Chemical Property of 3',4'-dideoxy-3'-fluorokanamycin A monocarbonate

Chemical Property:

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Technology Process of 3',4'-dideoxy-3'-fluorokanamycin A monocarbonate

There total 5 articles about 3',4'-dideoxy-3'-fluorokanamycin A monocarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₄₃FN₄O₉

: 134160-39-7
3',4'-dideoxy-3'-fluorokanamycin A monocarbonate

Guidance literature:: With acetic acid; at 80 ℃; for 0.5h; Yield given;
DOI:10.1016/0008-6215(91)80124-6

Reference yield:

: 134160-35-3
6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'-chloro-4'',6''-O-cyclohexylidene-3',4'-dideoxy-4'-epi-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A

: 134160-39-7
3',4'-dideoxy-3'-fluorokanamycin A monocarbonate

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / 1 M aq. NaOH / dioxane / Ambient temperature

2: 77 percent / Bu3SnH, α,α-azobis(isobutyronitrile) / dioxane / 2 h / 80 °C

3: liquid NH₃, Na / 0.08 h / -50 °C

4: 80percent aq. AcOH / 0.5 h / 80 °C

With sodium hydroxide; azobisisobutyronitrile; ammonia; tri-n-butyl-tin hydride; sodium; acetic acid; In 1,4-dioxane;
DOI:10.1016/0008-6215(91)80124-6

Reference yield:

: 134160-33-1
6',3''-di-N-acetyl-5,2''-di-O-acetyl-4'',6''-O-cyclohexylidene-3'-deoxy-3'-fluoro-1,3,6',3''-tetra-N-tosylkanamycin A

: 134160-39-7
3',4'-dideoxy-3'-fluorokanamycin A monocarbonate

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / SOCl₂, pyridine / CH₂Cl₂ / 1) dry ice-acetone cooling, 2) up to r. t., 5 h

2: 75 percent / 1 M aq. NaOH / dioxane / Ambient temperature

3: 77 percent / Bu3SnH, α,α-azobis(isobutyronitrile) / dioxane / 2 h / 80 °C

4: liquid NH₃, Na / 0.08 h / -50 °C

5: 80percent aq. AcOH / 0.5 h / 80 °C

With pyridine; sodium hydroxide; thionyl chloride; azobisisobutyronitrile; ammonia; tri-n-butyl-tin hydride; sodium; acetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1016/0008-6215(91)80124-6