methyl (1S,2S)-2-aminocyclohexane-1-carboxylate

Base Information

Chemical Name:methyl (1S,2S)-2-aminocyclohexane-1-carboxylate
CAS No.:217799-18-3
Molecular Formula:C8H15 N O2
Molecular Weight:157.2102
Hs Code.:
DSSTox Substance ID:DTXSID70449987
Nikkaji Number:J1.078.747E
Wikidata:Q82269545
Mol file:217799-18-3.mol

Synonyms:217799-18-3;methyl (1S,2S)-2-aminocyclohexane-1-carboxylate;(1S,2S)-Methyl 2-aminocyclohexanecarboxylate;methyl trans-2-aminocyclohexanecarboxylate;SCHEMBL6079072;DTXSID70449987;SUYHWZRODJBJER-BQBZGAKWSA-N;161618-50-4;AMY14697;AC4604;Cyclohexanecarboxylic acid, 2-amino-, methyl ester, (1S,2S)- (9CI);AKOS006372534;(1S,2S)-Methyl2-aminocyclohexanecarboxylate;methyl (1S,2S)-2-aminocyclohexanecarboxylate;(1S)-2beta-Aminocyclohexane-1alpha-carboxylic acid methyl ester

Suppliers and Price of methyl (1S,2S)-2-aminocyclohexane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of methyl (1S,2S)-2-aminocyclohexane-1-carboxylate

Chemical Property:

PSA：52.32000
LogP:1.37720
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:157.110278721
Heavy Atom Count:11
Complexity:147

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1CCCCC1N
Isomeric SMILES:COC(=O)[C@H]1CCCC[C@@H]1N

Technology Process of methyl (1S,2S)-2-aminocyclohexane-1-carboxylate

There total 4 articles about methyl (1S,2S)-2-aminocyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932743-49-2
6-benzylamino-cyclohex-1-enecarboxylic acid methyl ester

: 217799-18-3,161618-52-6
(1S,2S)-2-aminocyclohexanecarboxylic acid methyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In ethyl acetate; for 18h;
DOI:10.1021/ol0700207

Reference yield:

: 865780-25-2
methyl 6-hydroxy-cyclohex-1-enecarboxylate

: 217799-18-3,161618-52-6
(1S,2S)-2-aminocyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / DMAP / CHCl₃; pyridine / 2 h / 20 °C

2: 99 percent / chiral diaminophosphine oxide; BSA / [η³-C3H5PdCl]2 / acetonitrile / 24 h / -30 °C

3: H₂ / Pd(OH)2/C / ethyl acetate / 18 h

With benzenesulfonamide; dmap; chiral diaminophosphine oxide; hydrogen; palladium dihydroxide; bis(η3-allyl-μ-chloropalladium(II)); In pyridine; chloroform; ethyl acetate; acetonitrile;
DOI:10.1021/ol0700207

Reference yield:

: 225779-46-4
6-methoxycarbonyloxycyclohex-1-enecarboxylic acid methyl ester

: 217799-18-3,161618-52-6
(1S,2S)-2-aminocyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / chiral diaminophosphine oxide; BSA / [η³-C3H5PdCl]2 / acetonitrile / 24 h / -30 °C

2: H₂ / Pd(OH)2/C / ethyl acetate / 18 h

With benzenesulfonamide; chiral diaminophosphine oxide; hydrogen; palladium dihydroxide; bis(η3-allyl-μ-chloropalladium(II)); In ethyl acetate; acetonitrile;
DOI:10.1021/ol0700207