(R)-benzyl 2-((R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate

Base Information

Chemical Name:(R)-benzyl 2-((R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate
CAS No.:1024829-63-7
Molecular Formula:C₂₇H₃₆N₂O₅
Molecular Weight:468.593
Hs Code.:

Synonyms:(R)-benzyl 2-((R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-benzyl 2-((R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate

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Technology Process of (R)-benzyl 2-((R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate

There total 1 articles about (R)-benzyl 2-((R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18942-49-9
Boc-D-Phe-OH

: 17664-93-6
(R)-benzyl 2-amino-4-methylpentanoate p-toluenesulfonate salt

: 1024829-63-7
(R)-benzyl 2-((R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/acsmedchemlett.0c00287

Reference yield:

: 1024829-63-7
(R)-benzyl 2-((R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate

: 76-05-1
trifluoroacetic acid

: 1024829-66-0
C₂HF₃O₂*C₂₂H₂₈N₂O₃

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1024829-63-7
(R)-benzyl 2-((R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate

: C₄₅H₆₈N₆O₉

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h

2: (R)-benzyl 4-methyl-2-((R)-3-phenyl-2-(2-(((1-phenylcyclopropyl)methyl)amino) acetamido)propanamido)pentanoate; HATU / N,N-dimethyl-formamide / 2 h / 0 °C

3: hydrogen; palladium on activated charcoal / methanol / 12 h / 20 °C

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With hydrogenchloride; palladium on activated charcoal; (R)-benzyl 4-methyl-2-((R)-3-phenyl-2-(2-(((1-phenylcyclopropyl)methyl)amino) acetamido)propanamido)pentanoate; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.0c00287